Reassessment and reclassification of variants of unknown significance in patients with cardiomyopathy in a specialist department.

Background: The utility of diagnostic genetic testing in cardiomyopathy has grown significantly, due to the discovery of novel genes and greater awareness among healthcare professionals. However, a substantial proportion of cases (around 50%) yield no causative genetic variants or have variants of unknown significance (VUS), limiting their use in clinical management and familial screening. The increase in data quantity and quality in reference databases, coupled with variant interpretation guidelines, allows for periodic reanalysis of VUS, potentially reducing diagnostic gaps.

Population dynamics of a South African isolate of liquid culture, using egg yolk as protein source.

The entomopathogenic nematode (EPN), , is an effective biological control agent against a variety of important insect pests in South Africa. To develop a South African EPN product feasibly in South Africa, EPNs need to be mass-produced. This study aimed to record the population dynamics of with liquid production in shake flasks, with a protein source of powdered egg yolk.

Photorhabdus viridis sp. nov. Isolated from Heterorhabditis zealandica Entomopathogenic Nematodes.

A novel bacterial species, Photorhabdus viridis sp. nov., represented by strain Green, isolated from Heterorhabditis zealandica MJ2C entomopathogenic nematodes, is described.

Potential benefits of marine-derived compounds for slowing the advancement of Alzheimer's disease.

The incidence of Alzheimer's is increasing and poses a significant social and economic burden. The pathogenesis involved in the expansion of AD includes neuronal oxidative damage, tau phosphorylation, amyloid beta aggregation, neuroinflammation, etc. Despite enormous efforts, there is currently no effective treatment or cure for this condition in the allopathic system.

An ICT-enabled community oriented primary care intervention in mining communities during COVID-19 (2019-2022): perceived changes in the role and place of community health workers.

Background: This is a study of service provider perceptions of the place, role and practices of CHWs in a four-year, large-scale private sector funded, public service ICT-enabled COPC intervention with rural and remote mining communities. Like all South African communities, apart from large mining house employees and some contractors, most people use available public healthcare services and private traditional as well as limited allopathic private sector providers. In addition to the limitations of facility centred primary healthcare and a fragmented health care system, the many negative health effects of mining on the communities, go unattended.