Publications by authors named "A Majer"

Article Synopsis
  • Menin, a protein encoded by a specific gene, acts as a nuclear scaffold that regulates gene expression by interacting with chromatin modifiers and transcription factors.
  • Its role in cancer is complex, as it can function as both a tumor suppressor in conditions like MEN1 syndrome and cholangiocarcinoma, and as a tumor promoter in various other cancers like leukemia and colorectal cancer, depending on the type and context of the tumor.
  • The review focuses on the diverse roles of menin across different cancer types, emphasizing the need for further research to understand its mechanisms and therapeutic potential.
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Due to their tissue structure similar to mammalian skin and their close evolutionary relationship with chordates, holothurians (Echinodermata: Holothuroidea) are particularly interesting for studies on wound healing. However, previous studies dealing with holothuroid wound healing have had limited approaches, being restricted to tissue repair or perivisceral immune response. In this study, we combined tissue, cellular and humoral parameters to study the wound healing process of Holothuria grisea.

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Species interact in different ways, including competition, facilitation and predation. These interactions can be non-linear or higher order and may depend on time or species densities. Although these higher-order interactions are virtually ubiquitous, they remain poorly understood, as they are challenging both theoretically and empirically.

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The pathophysiology of many neuropsychiatric disorders is still poorly understood. Identification of biomarkers for these diseases could benefit patients due to better classification and stratification. Exosomes excreted into the circulatory system can cross the blood-brain barrier and carry a cell type-specific set of molecules.

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Metal accumulation is used by some plants as a defence against herbivores. Yet, herbivores may adapt to these defences, becoming less susceptible. Moreover, ecosystems often contain plants that do and do not accumulate metals, but whether such heterogeneity affects herbivore adaptation remains understudied.

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