Publications by authors named "A Maillet"
Bedrest shifts fasting and postprandial fuel selection towards carbohydrate use over lipids, potentially affecting astronauts' performance and health. We investigated whether this change occurs in astronauts after at least 3 months onboard the International Space Station (ISS). We further explored the associations with diet, physical activity (PA), and body composition.
View Article and Find Full Text PDFFuture long-duration human spaceflight will require developments to limit biocontamination of surface habitats. The MATISS (Microbial Aerosol Tethering on Innovative Surfaces in the international Space Station) experiments allowed for exposing surface treatments in the ISS (International Space Station) using a sample-holder developed to this end. Three campaigns of FDTS (perFluoroDecylTrichloroSilane) surface exposures were performed over monthly durations during distinct periods.
View Article and Find Full Text PDFArticle Synopsis
- Astronauts experience body mass loss and changes in body composition during long-term space missions, with a study observing these effects over 6 months on the International Space Station.* -
- Measurements taken from 11 astronauts showed a significant decrease in body mass, primarily due to changes in physical activity and energy expenditure, with notable differences between individuals' responses to exercise.* -
- Those who maintained higher energy expenditure while in space managed to preserve their fat-free mass, while others who decreased physical activity experienced a reduction in fat-free mass and an increase in body fat.*
Article Synopsis
- Fatigue is a common and significant issue experienced by patients in the early stages of Parkinson's disease (PD), impacting their quality of life significantly.
- A study involving 197 new PD patients showed that fatigue correlates strongly with higher levels of apathy and depression, as well as anxiety, with nearly 29% of patients reporting fatigue.
- The findings suggest that fatigue should be considered as a key component of the neuropsychiatric triad (apathy, depression, anxiety) in PD, indicating a need for better management strategies.
Article Synopsis
- This study investigates the progression of dopaminergic and serotonergic dysfunction in newly diagnosed Parkinson's disease (PD) patients with or without apathy and its impact on their motor and nonmotor symptoms.
- Using a longitudinal study with PET scans, researchers found that while both patient groups experienced similar progression in motor issues, apathetic patients showed compensatory changes in serotonergic function that helped reduce their apathy over time.
- Overall, results suggest that serotonergic plasticity may play a role in reversing apathy in PD patients, highlighting the need for further exploration of these compensatory mechanisms after starting dopamine replacement therapy.