Publications by authors named "A Maier"
An expert consensus statement on biomarkers of ageing for use in intervention studies.
J Gerontol A Biol Sci Med Sci
December 2024
Biomarkers of ageing serve as important outcome measures in longevity-promoting interventions. However, there is limited consensus on which specific biomarkers are most appropriate for human intervention studies. This work aimed to address this need by establishing an expert consensus on biomarkers of ageing for use in intervention studies via the Delphi method.
View Article and Find Full Text PDFHerein, novel, superabsorbent, and pH-responsive hydrogels obtained by the photochemical cross-linking of hydrophilic poly(vinylphosphonates) are introduced. First, statistical copolymers of diethyl vinylphosphonate (DEVP) and diallyl vinylphosphonate (DAlVP) are synthesized via rare earth metal-mediated group-transfer polymerization (REM-GTP) yielding similar molecular weights ( = 127-142 kg/mol) and narrow polydispersities ( < 1.12).
View Article and Find Full Text PDFMultifunctional, biocompatible magnetic materials, such as iron oxide nanoparticles (IONPs), hold great potential for biomedical applications including diagnostics (e.g., MRI) and cancer therapy.
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- The study investigates the impact of neurodevelopmental disorders (NF1, TSC, FXS, and NS) on brain volume, particularly focusing on global and subcortical structures, to understand disease mechanisms.
- A meta-analysis of 23 studies involving 1,556 subjects revealed that NF1 and FXS are associated with larger brain volumes, while NS shows smaller brain volumes.
- Notably, TSC showed no significant differences in brain volume compared to typical controls, with no moderating effects from age, sex, or IQ observed across studies.
Article Synopsis
- The study investigates whether different sedation depths during targeted temperature management (TTM) can affect neurological outcomes in post-cardiac arrest patients.
- It analyzed data from a medical ICU over several years, comparing patients sedated to a RASS-target of -5 versus -4, focusing on favorable neurological outcomes defined as a Cerebral Performance Category (CPC) score of 1 or 2.
- The results suggest that lighter sedation (RASS-target -4) is linked to better neurological outcomes and 30-day survival rates compared to deeper sedation (RASS-target -5), indicating a need for further research in this area.