Publications by authors named "A Mahdhi"
Article Synopsis
- Idiopathic Pulmonary Fibrosis (IPF) is a serious lung disease linked to the protein TGF-β1, which promotes lung tissue scarring and is affected by specific genetic mutations.
- The study analyzed how certain harmful SNPs (genetic variations) of the TGF-β1 gene influence its structure and function, using various computational tools to assess protein stability and interaction effects.
- Findings revealed 14 key genetic variants that destabilize the TGF-β1 protein, affecting its ability to function properly, which could have implications for understanding and treating IPF.
Article Synopsis
- Preeclampsia is a complex condition linked to high blood pressure and organ dysfunction, which can be diagnosed even without protein in urine.
- The condition involves immune interactions between the mother and fetus, where mechanisms like reduced major histocompatibility complex expression help the fetus evade the mother's immune response.
- Regulatory T cells and decidual natural killer cells play crucial roles in regulating fetal development and promoting necessary changes in the blood vessels of the uterus for a healthy pregnancy.
Over the last decade, we were facing medical struggle by the emergence of multi-resistant bacteria, especially methicillin-resistant (MRSA). MRSA infections are still causing a growing global concern due to the rapid adaptive multidrug resistance to conventional antibiotics in human, community and veterinary medicine. Here we provide an overview about MRSA epidemiology, transmission and alternative potential treatments particularly new discovered phytochemicals with biological activity.
View Article and Find Full Text PDFThe growing prevalence of resistance to antibiotics potentially makes and serious pathogens, necessitating the development of new antimicrobial agents. We extracted crude biosurfactants from a potential probiotic spp. to control pathogenic bacteria associated with aerobic vaginal infection.
View Article and Find Full Text PDFAs part of the valorization of agricultural waste into bioactive compounds, a series of structurally novel oleanolic acid ((3β-hydroxyolean-12-en-28-oic acid, )-phtalimidines (isoindolinones) conjugates - bearing 1,2,3-triazole moieties were designed and synthesized by treating an azide previously prepared from isolated from olive pomace ( L.) with a wide range of propargylated phtalimidines using the Cu(I)-catalyzed click chemistry approach. and its newly prepared analogues, - were screened in vitro for their antibacterial activity against two Gram-positive bacteria, and , and two Gram-negative bacteria, and .
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