Publications by authors named "A Magee"
Front Behav Neurosci
September 2024
Article Synopsis
- Anxiety is a common non-motor symptom of Parkinson's disease that can begin before noticeable motor symptoms, with a higher prevalence in females despite the disease being more common in males.
- A study used young adult mice with a specific mutation related to Parkinson's to investigate differences in stress-induced anxiety behaviors between male and female subjects, revealing no baseline differences in anxiety responses.
- Following chronic stress, male mice showed different responses compared to their wildtype counterparts but female mice exhibited similar anxiety reactions to stress regardless of mutation, highlighting a significant sex-specific difference in how the mutation affects stress-related anxiety behaviors.
Article Synopsis
- Identification of stearoyl-CoA desaturase (SCD) as a key therapeutic target in improving the outcomes of acute myeloid leukemia (AML) patients, showing its role across different mutational backgrounds.
- Inhibition of SCD using the drug SSI-4 induces lipotoxicity, leading to cell death in AML models both in lab conditions and in living organisms.
- The study suggests that combining SCD inhibition with standard chemotherapy enhances the effectiveness of treatment, emphasizing the need for predictive biomarkers and combination therapies for optimal results.
Article Synopsis
- Nigeria reported its first mpox cases in nearly 40 years five years before the 2022-2023 outbreak, with ongoing human-to-human transmission driving the epidemic.
- Researchers analyzed 112 mpox virus genomes from Nigeria (2021-2023) and traced the lineage back to its emergence around July 2014 from southern Nigeria, specifically Rivers State.
- The study also found that human-to-human transmission significantly increased the virus's evolutionary rate and emphasized the importance of better pathogen surveillance and response strategies.
Article Synopsis
- Nigeria and Cameroon reported their first mpox cases in over 30 years starting in 2017 and 2018, with Nigeria's outbreak recognized as a human epidemic.
- The study focused on understanding the zoonotic transmission dynamics of the mpox virus across the Nigeria-Cameroon border, revealing ongoing cases driven by a new Clade IIb.1 lineage and highlighting significant cross-border viral spread.
- The findings indicate that southern Nigeria is likely the origin of the mpox epidemic, with evidence of a zoonotic precursor lineage present in local animal populations for over 45 years, emphasizing the persistent risk of MPXV emergence in both countries.
