Publications by authors named "A Magaret"
Background: Reproductive life planning is key, now that people with cystic fibrosis (pwCF) may live into their 60s. This study explores contraceptive use, pregnancy trends, and whether concomitant cystic fibrosis transmembrane conductance regulator (CFTR) modulator therapy reduces contraceptive effectiveness.
Methods: Females with CF aged 18-45 years from 10 U.
Baseline-dependent improvement in CF studies, plausibility of bias.
Contemp Clin Trials Commun
December 2024
Background: It has been commonly reported that therapeutic treatments in cystic fibrosis (CF) have ceiling effects, such that their efficacy is diminished for persons with high pre-treatment health (Montgomery et al., 2012 and Newsome et al., 2019).
View Article and Find Full Text PDFClinical trials often demonstrate treatment efficacy through change in forced expiratory volume in one second (FEV), comparing single FEV measurements from post- versus pre-treatment timepoints. Day-to-day variation in measured FEV is common for reasons such as diurnal variation and intermittent health changes, relative to a stable, monthly average. This variation can alter estimation of associations between change in FEV and baseline in predictable ways, through a phenomenon called regression to the mean.
View Article and Find Full Text PDFArticle Synopsis
- The study investigates the immune response to HSV-2 reactivation by examining T cells in skin biopsies and blood samples before and after vaccination with an HSV-2 candidate vaccine (HSV529).
- After the first vaccine dose, there was a notable increase in HSV-2-specific CD4+ T cell sequences from blood that made their way into the skin, indicating a successful immune memory response.
- Unique T cell clones were identified in the skin that weren't found in the blood, suggesting that the skin has a distinct immune profile, and highlights the importance of studying tissue-specific immunity in vaccine responses.