Publications by authors named "A Maestroni"
Article Synopsis
- The study focuses on identifying markers that can predict adverse events in patients who had acute myocarditis (AM) to optimize follow-up care.
- Researchers analyzed data from 248 AM patients, revealing that complicated clinical presentation (CCP) is a strong predictor of major cardiac events compared to other factors like septal late gadolinium enhancement and left ventricular ejection fraction.
- Findings indicate that while major events post-AM are rare, using CCP, LGE, and LVEF<50% together is effective for identifying those at risk, aiding clinicians in patient monitoring.
Glucagon-like peptide-1 receptor (GLP-1R) is a key regulator of glucose metabolism known to be expressed by pancreatic β cells. We herein investigated the role of GLP-1R on T lymphocytes during immune response. Our data showed that a subset of T lymphocytes expresses GLP-1R, which is upregulated during alloimmune response, similarly to PD-1.
View Article and Find Full Text PDFTMEM219 regulates the transcription factor expression and proliferation of beta cells.
Front Endocrinol (Lausanne)
February 2024
Pancreatic beta cells replenishment is considered the next therapeutic option for type 1 diabetes; while stimulating endogenous beta cells proliferation is the "holy grail" for those patients with exhausted beta cell mass. Here we are demonstrating that the pro-apoptotic receptor TMEM219 is expressed in fetal pancreas, in beta cell precursors and in embryonic-derived endocrine progenitors. TMEM219 signaling negatively regulates beta cells at early stages and induces Caspase 8-mediated cell death.
View Article and Find Full Text PDFDiabetic kidney disease (DKD) is the first cause of end-stage kidney disease in patients with diabetes and its prevalence is increasing worldwide. It encompasses histological alterations that mainly affect the glomerular filtration unit, which include thickening of the basement membrane, mesangial cell proliferation, endothelial alteration, and podocyte injury. These morphological abnormalities further result in a persistent increase of urinary albumin-to-creatinine ratio and in a reduction of the estimated glomerular filtration rate.
View Article and Find Full Text PDFBackground: Well-developed collaterals are assumed as a marker of viability and ischemia in chronic total occlusions (CTO). We aim to correlate viability and ischemia with collateral presence and extent in CTO patients by cardiac magnetic resonance (CMR).
Methods: Multicentre study of 150 CTO patients undergoing stress-CMR, including adenosine if normal systolic function, high-dose-dobutamine for patients with akinetic/>2 hypokinetic segments and EF ≥35%, otherwise low-dose-dobutamine (LDD); all patients underwent late gadolinium enhancement (LGE) imaging.