Publications by authors named "A Madbouly"
Background: Yellow (stripe) rust of wheat, caused by Puccinia striiformis, is a serious disease that results in great economic losses. This study aimed to investigate the variation in plant responses in three wheat cultivars with different resistance levels against yellow rust.
Results: The highest disease severity was recorded for cv.
Article Synopsis
- Modern histocompatibility algorithms analyze high-resolution HLA protein sequences to enhance epitope-based models for antibody or T cell interactions, with genotype imputation improving accuracy, especially when considering an individual's ancestry.
- The study compares molecular matching scores from high-resolution genotypes to those derived from low-resolution imputed genotypes using both simulated and real datasets.
- Results show that multiple imputation leads to lower errors in matching scores, and proper ancestry assumptions can further improve accuracy, making imputation a useful method for epitope analysis when used thoughtfully.
Article Synopsis
- Questions remain about the role of race and geographic ancestry in biomedical research, particularly how they can enhance matching algorithms for human leukocyte antigen (HLA) in stem cell transplants from donor registries.
- Analysis of self-reported racial and ancestral data from over 100,000 U.S. bone marrow donors shows discrepancies among these measures; using both race and geographic ancestry together yields the best fit for HLA genetic ancestry.
- The findings suggest that while direct matching for transplants doesn't use these data, incorporating both race and geographic ancestry is valuable for improving predictions of HLA compatibility in donor registries.
Background: Despite advances in treatment, pancreatic cancer frequently has a low survival rate due to its advanced-stage diagnosis. Treatment focuses on prolonging survival and maintaining quality of life. This study investigates the characteristics associated with survival in advanced pancreatic cancer patients treated at a single academic cancer center in Najran, Saudi Arabia.
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- The study explores the use of molecular mismatch analysis to predict graft rejection risk in kidney transplants by assessing the compatibility of donor and recipient HLA proteins.
- Imputation, or algorithmic assignment of high-resolution genotyping, was found to maintain the accuracy of risk categories for graft rejection in a significant majority of cases, even in racially diverse pairs.
- The results suggest that using imputation is a valuable approach in clinical settings for better predicting long-term graft survival after transplantation.