The effect of naloxone and the kappa antagonist MR 1452 MS on myocardial infarction in rats.

The intravenous infusion of naloxone (Nal) (0.17 mg/kg/min) and of the selective kappa antagonist MR 1452 MS (0.07 mg/kg/min) on rats with left coronary artery occlusion was studied.

Opioid peptides in experimental myocardial infarction. I. The effect of naloxone.

The effect of intravenous administration of the opioid antagonist naloxone in rats with acute left coronary artery ligation was studied. The results demonstrated that naloxone in a dose 2 mg/kg b. w.

Changes of adrenal vasopressin during hemorrhagic shock in rats with hereditary diabetes insipidus (Brattleboro strain).

The adrenal gland of the Brattleboro rat contains AVP-like immunoassayable material in amounts equal to those of the normal Long Evans animal--6.180 ng/g fresh tissue in LE and 6.108 ng/g fresh tissue in the Brattleboro rats.

Effect of specific opioid-receptor antagonist naloxone on rats with hereditary hypothalamic diabetes insipidus (Brattleboro strain) during acute hemorrhagic shock.

The development of an acute hemorrhagic shock in rats with hereditary diabetes insipidus (DI), lacking vasopressin, is very dramatic, compared to rats of the parent strain Long Evans (LE). After removal of 50% of the circulating blood for LE, and 30% for DI, the mortality for both LE and DI groups was 50%, the shock index being 0.049 and 0.