Publications by authors named "A Machens"
Background: Whether inherited in the context of multiple endocrine neoplasia 2B at germline level or acquired in a lifetime, all RET p.M918T (RET c.2753T>C) mutations should activate the RET tyrosine kinase receptor alike, with similar degrees of medullary thyroid cancer (MTC) progression when disparities in disease onset and multifocal growth are accounted for.
View Article and Find Full Text PDFPurpose: The tumor microenvironment often induces a scarring process known as tumor fibrosis or desmoplasia, which plays an important role in the initiation, progression, and clinical outcome of many types of cancer. This report aimed to highlight recent progress made in the field of de-escalation surgery for sporadic medullary thyroid cancer (MTC), building a bridge from basic science to current and emerging medical practice.
Methods: This narrative review entails a holistic description and interpretation of the English-language literature on MTC desmoplasia.
Article Synopsis
- There are two types of medullary thyroid cancer (MTC): hereditary and sporadic.
- Hereditary MTC often shows multiple tumors, while sporadic MTC isn't as clear about why it has multiple tumors.
- In sporadic MTC, tumors are connected to other serious issues like spreading to lymph nodes, but in hereditary MTC, it mainly relates to tumor size and how many tumors are present.