Publications by authors named "A Maaser"
Article Synopsis
- - Advanced paternal age (APA) is linked to increased risk for neurodevelopmental disorders like autism and schizophrenia, with correlations found between APA and personality traits such as schizotypy and neuroticism in healthy individuals.
- - The study reveals that higher paternal age is associated with increased gray matter volume in specific brain regions and suggests a connection between APA and brain connectivity through fiber tracts.
- - In a rat model, APA led to social-communication deficits and behavioral issues, with alterations in microRNA expression observed in both human and rat subjects, indicating potential epigenetic mechanisms at play that affect brain development and social behavior.
Article Synopsis
- * The analysis discovered 30 significant genetic loci linked to bipolar disorder, including 20 that hadn't been previously identified, which involve genes related to ion channels and neurotransmitter systems.
- * The study also showed that Bipolar I disorder has a genetic connection to schizophrenia, particularly linked to psychosis, while Bipolar II disorder is more closely related to major depressive disorder, shedding light on potential biological mechanisms and clinical implications.
Bipolar disorder (BD) is a major psychiatric illness affecting around 1% of the global population. BD is characterized by recurrent manic and depressive episodes, and has an estimated heritability of around 70%. Research has identified the first BD susceptibility genes.
View Article and Find Full Text PDFProfessional phagocytic cells such as macrophages are a central part of innate immune defence. They ingest microorganisms into membrane-bound compartments (phagosomes), which acidify and eventually fuse with lysosomes, exposing their contents to a microbicidal environment. Gram-positive Rhodococcus equi can cause pneumonia in young foals and in immunocompromised humans.
View Article and Find Full Text PDFArticle Synopsis
- A study investigated the genetic overlap between 25 brain disorders using data from over 1.2 million individuals, finding that psychiatric disorders share more genetic risk compared to neurological disorders, which seem more distinct.
- The research identified significant relationships between these disorders and various cognitive measures, suggesting shared underlying traits.
- Simulations were conducted to understand how factors like sample size and diagnosis accuracy influence genetic correlations, emphasizing the role of common genetic variations in the risk of brain disorders.