Publications by authors named "A M van Vuuren"
Upper age limits are currently fixed for all fecal immunochemical test (FIT)-based colorectal cancer (CRC) screening programs. A risk-stratified upper age limit may be beneficial. Therefore, we assessed differences in interval CRC risk among individuals who had reached the upper age limit of screening (75 years).
View Article and Find Full Text PDFHarm-to-Benefit Ratio of Fecal Immunochemical Test-Based Screening for Colorectal Cancer Given Prior Fecal Hemoglobin Concentrations.
Clin Gastroenterol Hepatol
October 2024
Background And Aims: This study aimed to provide evidence on the harm-to-benefit ratio of fecal immunochemical test (FIT)-based colorectal cancer (CRC) screening by previous fecal hemoglobin (f-Hb) concentrations, as reflected in the number needed to screen (NNS) and number needed to scope (NNSc).
Methods: Participants in up to 4 FIT screening rounds of the Dutch CRC screening program were included. The main outcomes of this study were the NNS and NNSc to detect 1 CRC and/or advanced neoplasia (AN) in screening rounds 2, 3, or 4, conditional on previous f-Hb concentrations.
Background And Aims: High temperatures may reduce fecal immunochemical test (FIT) positivity and colorectal cancer (CRC) detection sensitivity. We investigated the effect of temperature on hemoglobin concentration [Hb], in the FOB Gold®. Additionally, we examined FIT pick-up, storage, return times and specimen collection.
View Article and Find Full Text PDFArticle Synopsis
- Testicular cancer survivors (TCS) who received platinum-based chemotherapy are at a higher risk for developing colorectal cancer (CRC) compared to average-risk individuals.
- A study involving TCS from four Dutch hospitals found that 8.7% of them had advanced neoplasia, significantly higher than the 1.7% found in matched controls.
- The results indicate that TCS have a greater prevalence of colorectal neoplasia and advanced neoplasia, suggesting that colonoscopy screenings may be beneficial for this group; further cost-effectiveness studies are needed to determine the best screening practices.
Background: In the Dutch colorectal (CRC) screening program, fecal immunochemical test (FIT)-positive individuals are referred for colonoscopy. If no relevant findings are detected at colonoscopy, individuals are reinvited for FIT screening after 10 years. We aimed to assess CRC risk after a negative colonoscopy in FIT-positive individuals.
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