Publications by authors named "A M de Guzman"
Introduction: Immunodeficiencies are disturbances in the immune system that can affect cell function, quantity, or both. They can be either primary, associated with genetic defects, or secondary, linked to external factors such as hemato-oncological conditions. Secondary immunodeficiencies can lead to the initiation, reactivation, or acceleration of latent, residual, or active infections, which are the leading cause of mortality.
View Article and Find Full Text PDFMultidimensional Effects of Stress on Neuronal Exosome Levels and Simultaneous Transcriptomic Profiles.
Biol Psychiatry Glob Open Sci
January 2025
Background: An excess of exosomes, nanovesicles released from all cells and key regulators of brain plasticity, is an emerging therapeutic target for stress-related mental illnesses. The effects of chronic stress on exosome levels are unknown; even less is known about molecular drivers of exosome levels in the stress response.
Methods: We used our state-of-the-art protocol with 2 complementary strategies to isolate neuronal exosomes from plasma, ventral dentate gyrus, basolateral amygdala, and olfactory bulbs of male mice to determine the effects of chronic restraint stress (CRS) on exosome levels.
Article Synopsis
- The Cucurbitaceae family, known for its bioactive compounds, is being studied for its potential in preventing and treating colorectal cancer (CRC).
- Four different extracts from cucurbit leaves and seeds were tested on various CRC cell lines to evaluate their effects on tumor growth and cell health.
- Cold ethanolic extracts showed significant anti-cancer properties, such as inhibiting cell proliferation and angiogenesis, and were linked to specific cell cycle changes and gene expression modifications, suggesting they could enhance CRC treatment strategies.
Purpose: To develop and test a novel optical coherence tomography (OCT) metric for the detection of glaucoma based on a logistic regression model (LRM) and known patterns of glaucomatous damage.
Methods: The six variables of the LRM were based on characteristic patterns of damage seen on the OCT thickness maps of the ganglion cell layer plus inner plexiform layer (GCL+) and retinal nerve fiber layer (RNFL). Two cohorts were used to develop the LRM.
Article Synopsis
- Floral traits like flower size and nectar/pollen rewards are crucial for attracting pollinators, but these traits can vary due to environmental factors and soil conditions.
- Research shows that diverse arbuscular mycorrhizal fungi (AMF) can improve floral displays and rewards, leading to increased bee visitation, as larger flowers attract more bees.
- However, there's a trade-off, as enhanced flower size from AMF may reduce root colonization, indicating that soil microbial interactions significantly influence both plant traits and pollinator behavior.