Cytomegaloviral Infections in Recipients of Chimeric Antigen Receptor T-Cell Therapy: An Observational Study With Focus on Oncologic Outcomes.

Background: Patients with B-cell lymphoma and acute lymphoblastic leukemia (ALL) who receive chimeric antigen receptor T-cell (CAR-T) therapy may experience clinically significant cytomegalovirus infection (CS-CMVi). However, risk factors for CS-CMVi are not well defined. The aims of our study were to identify risk factors for CS-CMVi and the association between CS-CMVi and nonrelapse mortality (NRM) in lymphoma and ALL patients after CAR-T therapy.

[Diagnosis of rare forms of breast desmoid tumor].

Desmoid is a rare tumor that is intermediate between benign and malignant neoplasms. Clinical, laboratory, and instrumental evidence shows the signs characteristic for both neoplastic and benign processes. The purpose of our study is to present two breast desmoid cases observed in our clinic and to demonstrate all stages of this diagnosis, by using specific examples.

[Guanylate cyclase activity of the rabbit myocardium in normal conditions and in allergic states].

Activity of guanylate cyclase, regulation of the enzyme by means of hormones and other biologically active substances as well as level of cGMP were studied in rabbit myocardium of control animals and in animals with allergic impairment of the tissue. The enzyme was shown to exhibit no sensitivity to acetylcholine and histamine, which appears to occur as a result of the hormone-unspecific desensitization of the corresponding receptors in allergic impairment. Decreased basal activity of guanylate cyclase was accompanied by an increase in content of cGMP in myocardial tissue.

[Mechanism of disruption in the metabolism of the cyclic AMP system in myocardial tissue in allergic deterioration].

Role of hormones, guanylic nucleotides and sodium fluoride in regulation of adenylate cyclase activity was studied in rabbit heart under conditions of its allergic deterioration caused by repeated administration of horse blood serum. In the allergic injury activation of adenylate cyclase was found to occur simultaneously with a decrease in the rate of the enzyme stimulation by means of either the hormones in presence of guanylic nucleotides or by sodium fluoride. Without guanylic nucleotides the hormones did not stimulate adenylate cyclase activity.

[Acute emotional stress and cyclic nucleotide content of the heart and blood plasma].

The relationships between the changes in arterial pressure and the content of cyclic nucleotides in the heart and blood plasma were studied on rabbits exposed to acute emotional stress. During 3 hours of the stress program, there were changes in arterial pressure, namely an elevation within the first hour followed by a progressive fall during subsequent 2 hours and death of the animals. The content of cAMP in the heart rose to a greater degree than that of cGMP.