[Pathogenetic basis for the correction of adaptation reactions in children using PILER-light].

According to the positions of systemic analysis of autoregulations and systemic reconstruction processes in children under the influence of PILER-light (Polarized polychromatic incoherent low-energy radiation) depending on the type of general non-specific adaptation reactions of the organism, the clinical blood test has been investigated using the correlation structures method. It has been established that phototherapy with polarized light causes stereotype effect of increased integration between the blood parameters, harmonizing of white and red blood parameters, elimination of the stress, decreased entropy elements. At the same time the specific adaptation reaction of the child's organism to the loadings of various origin, in particular, to the electromagnetic irradiation of optic diapason waves indicates the diverse character of the changed regulation system functions depending on the adaptation reaction type and grounds the differentiated approach to the polarized light therapy.

[Diagnostic value of immuno-hormonal relationships in adolescents in early primary tuberculosis infection].

The immunological and hormonal links of homeostasis and the pattern of their relationships were studied in 137 adolescents with early primary tuberculous infection (EPTI) and 79 adolescents uninfected with tuberculosis (control). There was a significant increase in the specific functional activity of T lymphocytes and a reduction in their nonspecific functional activity as compared with the controls, as well as an elevation of the levels of thyroxine, cortisol, and insulin. In EPTI, there was an unbalanced enhancement of the activity of cortisol and insulin with the relative deficiency of the latter, which is indicative of overstrain of nonspecific adaptation reactions.

[Immunological and hematological criteria of the prognostication of the effectiveness of tuberculosis chemoprophylaxis in children].

Immunological indices and hemograms were studied in 80 children early in the course of primary tuberculous infection to ascertain prognostic criteria of chemoprophylaxis efficacy. Of prognostic importance appeared: to be the Mantoux test with 2 TU PPD-L; T-lymphocyte, T-helpers, active T-lymphocytes, leukocyte, eosinophil count; leukocyte migration inhibition test with pulmonary antigen and BCG; hemogram assessment according to Garkavi and its dynamic changes 1 month after chemoprophylaxis. Basing on these prognostic criteria relevant algorithms have been derived.

[Specific risk factors of the development of early period of primary tuberculous infection in children].

The role of the tuberculosis contact and specific BCG immunoprophylaxis in the onset of early primary tuberculosis is investigated. Primary infection from tuberculous and healthy families depended on BCG quality, the number of BCG vaccination marks and postvaccination time. Upon the comparison of informative value of specific and nonspecific factors it was found that specific factors are leading in pathogenesis of present-day primary tuberculosis infection.

[Correlation of dermatoglyphic and cellular immunity parameters in children with early stage of primary tuberculosis].

Immunological status and dermatoglyphic characteristics were compared in 55 children aged 4-14 with a turn in tuberculin reactions. A correlation was established between genetic and immunological factors, this pointing to the fact that dermatoglyphics is a component of genotype indicative of natural resistance of children to tuberculosis. Synchronization between immunological and genetic values is less intensive in children with immunological disorders against those without them.