BAYESIAN MODELLING AND INFERENCE OF MIXTURES OF DISTRIBUTIONS OF MICRONUCLEAR BUCCAL CELLS IN THE POPULATION OF SACHKHERE DISTRICT'S VILLAGES.

Malignant tumors are one of the leading courses of mortality in the world, and it is believed that 19% of malignant tumors are associated with environmental risk factors. The aim of the study was to establish the spectrum of distributions of an informative biomarker of the unfavorable (genotoxic) effect of the external environment on the body by determining the level of micronuclei (LMN) in buccal epithelium cells in populations of villages of the Sachkhera region (Georgia). In the inhabitants of the Sachkhere district (both sexes, 50-65 years old) living in the villages of Sareki, Sairkhe, and Chorvila, LMN was determined in the cells of the buccal epithelium.

[Success factors for dental autotransplantation].

Autotransplantation provides the possibility of a natural tooth rather than a prothesis or an osseointegrated implant to replace a missing tooth. The indications for autotransplantation are wide, but careful patient selection coupled with an appropriate technique is a prerequisite for a good functional and esthetic outcome. This review article will identify and discuss the factors that influence case selection, the ideal timing for autotransplantation and the critical determinants for achieving a successful outcome.

[Useage of genetic markers to determine the impact of radiation on the human body].

The timely determination of the fact of radiation impact on the organism is extremely important for preventive and curative interventions. Despite the fact that so far cytogenetic violations are considered to be the best biomarkers to determine the impact of ionizing radiation on the organism, actual problem is to find the optimal combination of different biomarkers. The aim of the work was investigation of the extended set of biomarkers in distant periods of exposure in people previously assigned to the radiation risk group, as well as the identification of genetic disorders in the process of radiotherapy.

Chromosomes and causation of human cancer and leukemia. L. Cytogenetics of leukemias complicating other diseases.

Complicating (secondary) leukemias in 20 patients, 18 of whom had various forms of neoplasia treated with chemotherapy and/or radiation, have been examined in regard to the karyotypic findings present in the leukemic cells of the marrow. In addition, the published cases of complicating leukemia have been tabulated. Based on the results of the present study and those in the literature it appears that chromosomes #3 and #17 should be stressed as being nonrandomly involved in complicating leukemia in addition to the previously stressed chromosomes #5 and #7.