Publications by authors named "A M Wonneberger"

Article Synopsis
  • RORA is a gene linked to the development and function of the cerebellum, and this study explores the largest group of individuals with RORA-related neurodevelopmental disorders (RORA-NDD).
  • The study involved 40 participants with various pathogenic variants of RORA, revealing a range of clinical features including developmental and intellectual disabilities, as well as cerebellar symptoms that can vary in onset and severity.
  • Findings indicate that certain missense variants are associated with more severe cerebellar issues, and common elements of RORA-NDD include developmental disabilities, cerebellar symptoms, and different types of myoclonic epilepsy.
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Sociotechnical imaginaries of gene editing in food and agriculture reflect and shape culturally particular understandings of what role technology should play in an ideal agrifood future. This study employs a comparative media content analysis to identify sociotechnical imaginaries of agricultural gene editing and the actors who perform them in five countries with contrasting regulatory and cultural contexts: Canada, Japan, New Zealand, the Netherlands, and the United States. We find that news media in these countries reinforce a predominantly positive portrayal of the technology's future, although variations in which imaginaries are most mobilized exist based on the regulatory status of gene editing and unique histories of civil society engagement around biotechnology in each country.

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Objectives: To present a case series of novel variants in patients presenting with genetic epileptic and developmental encephalopathy.

Background: CHD2 gene encodes an ATP-dependent enzyme, chromodomain helicase DNA-binding protein 2, involved in chromatin remodeling. Pathogenic variants in CHD2 are linked to early-onset conditions such as developmental and epileptic encephalopathy, drug-resistant epilepsies, and neurodevelopmental disorders.

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The COVID-19 pandemic and climate change are two global crises that require collective action. Yet, the inertia typically associated with behavior change to limit climate change stands in contrast to the speed associated with behavior change to stop the spread of COVID-19. Identifying the roots of these differences can help us stimulate climate-friendly behaviors.

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