Publications by authors named "A M Wiersema"
Article Synopsis
- Neurodegenerative disorders like Alzheimer's, ALS, and Parkinson's affect millions, with a need for better understanding since no cures exist yet.
- Extracellular vesicles (EVs) are tiny particles that help in cell communication and may spread harmful proteins related to these diseases.
- The review focuses on recent findings about the role of EVs in these disorders, shared issues in their cargo, and potential therapeutic strategies.*
Purpose: To evaluate retrospectively the 2-year outcomes of the Gore Excluder Iliac Branch Endoprosthesis (IBE) in patients with and without coexisting hypogastric artery (HA) aneurysms in a large contemporary multicentric European experience using dedicated bridging devices.
Methods: The study included all consecutive patients treated at participating institutions with the Gore Excluder IBE device who received a covered stent (i.e.
Article Synopsis
- The study aimed to evaluate the short- and midterm results of catheter-directed thrombolysis (CDT) for treating acute lower limb ischemia (ALI), focusing on functional outcomes based on Rutherford classification.
- A total of 200 patients were analyzed, showing high initial clinical success rates and comparable complication rates between different Rutherford classes, with notable rates of reinterventions and amputations during follow-up.
- The findings suggest that successful initial treatment and less severe ischemia at presentation lead to better long-term functional outcomes for patients undergoing CDT.
Purpose: Acute lower limb ischemia (ALI) is a sudden decrease in arterial limb perfusion due to an arterial blockage, threatening limb and life. Catheter-directed thrombolysis (CDT) is a minimally invasive procedure to remove such obstructions. However, approximately one-third of patients endure a re-occlusion after successful CDT.
View Article and Find Full Text PDFBackground: Activated clotting time (ACT) measurements are frequently used to monitor unfractionated heparin activity during noncardiac arterial procedures (NCAP). Accuracy of ACT-guided heparinization is mandatory to prevent heparin under and overdosing, thereby minimizing thrombo-embolic complications (TECs) and bleeding risk. The main objective of this study was to investigate accuracy of ACT to monitor heparin activity during NCAP using the Hemostasis Management System Plus (HMS) with high-range (HR) cartridges.
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