Publications by authors named "A M Whipp"

Background: Separating with close siblings and leaving the parental home at an early age represents a major life event for an adolescent (reflected by age at separation in a twin pair) and may predispose them to poor mental health. This study aims to examine the association of age at separation and residential mobility on depressive symptoms in late adolescence and young adulthood and to explore possible underlying genetic effects.

Methods: Residential mobility consisted of the number and total distance of moves before age 17.

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Background: Adolescent mental health problems impose a significant burden. Exploring evolving social environments could enhance comprehension of their impact on mental health. We aimed to depict the trajectories of the neighborhood social exposome from middle to late adolescence and assess the intricate relationship between them and late adolescent mental health.

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Global emphasis on enhancing prevention and treatment strategies necessitates an increased understanding of the biological mechanisms of psychopathology. Plasma proteomics is a powerful tool that has been applied in the context of specific mental disorders for biomarker identification. The p-factor, also known as the "general psychopathology factor", is a concept in psychopathology suggesting that there is a common underlying factor that contributes to the development of various forms of mental disorders.

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Article Synopsis
  • The study investigates how genetics and environment influence the relationship between plasma proteins and body mass index (BMI) in adolescents and adults, linking these findings to other biological data (omics).
  • Using two cohorts of twins, researchers analyzed protein levels and their associations with BMI over time, revealing significant genetic and environmental factors affecting these proteins.
  • They identified 66 proteins linked to BMI and 14 related to changes in BMI, highlighting the complex interactions between genetic make-up, environmental influences, and protein abundance.
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Article Synopsis
  • The study investigates how different urban land use environments affect depressive symptoms in young adults, using data from 1804 twins in urban areas.
  • Two distinct clusters were identified: one resembling city centers and the other suburban areas, revealing variation in the impact of land use on mental health.
  • Results indicated that agricultural residential land use significantly influenced depressive symptoms in the suburban cluster, while no land use factors were linked to symptoms in the city center cluster, highlighting the complex and heterogeneous nature of these relationships.
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