The beauty of symmetry: siRNA phosphorodithioate modifications reduce stereocomplexity, ease analysis, and can improve potency.

Phosphorothioates (PSs) can be essential in stabilizing therapeutic oligonucleotides against enzymatic degradation. However, unless synthesis is performed with stereodefined amidites, each PS introduces a chemically undefined stereocenter, resulting in 2 unique molecules in the final product and affecting downstream analytics and purification. Replacing the second non-bridging oxygen with sulfur results in phosphorodithioate (PS2) linkages, thereby removing the stereocenter.

Autism and duplication of 17q12q21.2 by array-CGH: a case report.

Objective: Autism spectrum disorder (ASD) affects cognitive development and social interaction on different levels. Genetic and environmental factors are associated with secondary ASD. Genetic inheritance is mainly polygenic, and 10% are copy number variations (CNVs).

Digital images are hard to resist: Teaching viewers about the effects of camera angle does not reduce the camera angle's impact on power judgments.

Digital images on the internet are often designed to manipulate viewers' interpretations. Therefore, it is important to educate viewers regarding potential effects of such techniques. We investigated whether two interventions addressing potential effects of camera angle affect the technique's effect on participants' power-related judgments of depicted persons.

[Fatigue at Long COVID].

Persistent or new symptoms after infection with SARS-CoV-2 are common and are referred to as Long COVID. Fatigue is by far the most common symptom. The current article deals with fatigue in the context of Long COVID, attempts a pathogenetic classification and makes suggestions for appropriate treatment.

Whole-cell screening of oxidative enzymes using genetically encoded sensors.

Biocatalysis is increasingly used for synthetic purposes in the chemical and especially the pharmaceutical industry. Enzyme discovery and optimization which is frequently needed to improve biocatalytic performance rely on high-throughput methods for activity determination. These methods should ideally be generic and applicable to entire enzyme families.