Publications by authors named "A M Villamil"
This study examined the complexities surrounding migrants' health-seeking behaviors in the United States. Using intersectionality as a guiding analytic, we conducted in-depth interviews with 15 visa-holding migrants from West African, East, and Southeast Asian countries to understand their experiences navigating healthcare in another country. Participants mentioned the convergence of three power systems: nativity/language of origin status, education status, and migration (legal) status.
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- Obeticholic acid (OCA) was evaluated in the COBALT trial for its effectiveness in treating primary biliary cholangitis (PBC), showing mixed results in the randomized controlled trial (RCT) compared to external controls.
- In the RCT, similar rates of severe outcomes occurred between OCA and placebo groups, but issues like unblinding influenced the results; however, analysis adjustments gave OCA an advantage.
- The external control group indicated that OCA significantly lowered the risk of negative outcomes, highlighting its potential benefits for patients with PBC and endorsing the use of real-world data in clinical research.
Article Synopsis
- The study investigates the prognostic value of changes in liver stiffness measurement (LSM) over time in patients with primary biliary cholangitis (PBC) who are being treated with ursodeoxycholic acid.
- It utilizes data from 3,078 patients over a 19-year period, finding that 59% of participants had an increase in LSM, which is linked to a higher risk of serious clinical events such as cirrhosis complications and liver transplants.
- The research concludes that monitoring LSM changes provides essential prognostic information, suggesting its potential as a valuable endpoint in clinical trials for PBC treatment.
Background & Aims: Recurrent primary biliary cholangitis (rPBC) develops in approximately 30% of patients and negatively impacts graft and overall patient survival after liver transplantation (LT). There is a lack of data regarding the response rate to ursodeoxycholic acid (UDCA) in rPBC. We evaluated a large, international, multi-center cohort to assess the performance of PBC scores in predicting the risk of graft and overall survival after LT in patients with rPBC.
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