Publications by authors named "A M Van Dam"
Objectives: Mycoplasma genitalium, a sexually transmitted bacterium, faces increasing antibiotic resistance, particularly to azithromycin. However, presence of macrolide resistance-associated mutations (MRAMs) does not evidently implicate azithromycin treatment failure. This study aimed to establish an in vitro co-culture system of M.
View Article and Find Full Text PDFThe hydrogen-bond donor strength of ureas, widely used in hydrogen-bond donor catalysis, molecular recognition, and self-assembly, can be enhanced by increasing the size of the chalcogen X in the CX bond from O to S to Se and by introducing more electron-withdrawing substituents because both modifications increase the positive charge on the NH groups which become better hydrogen-bond donors. However, in 1,3-diaryl X-ureas, a steric mechanism disrupts the positive additivity of these two tuning factors, as revealed by our quantum-chemical analyses. This leads to an enhanced hydrogen-bond donor strength, despite a lower NH acidity, for 1,3-diaryl substituted O-ureas compared to the S- and Se-urea analogs.
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- A new species of beetle, named C. stonei sp. nov., has been discovered in Costa Rica while researching planthoppers linked to palm trees.
- The study includes molecular data from specific genes (COI, 18S rRNA, and 28S rRNA) to confirm the classification of this beetle within the Colpoptera genus.
- This research enhances the understanding of biodiversity in the Colpopterini tribe and the ecological relationships in palm ecosystems.
Article Synopsis
- This article discusses common questions and symptoms related to STDs that patients frequently raise with general practitioners and special clinics, emphasizing the importance of understanding sexual behavior in making accurate diagnoses.
- It highlights the need for careful risk assessment and testing policies, particularly for high-risk individuals who should be tested for gonorrhea, syphilis, HIV, and hepatitis B, while also addressing the significance of early detection and treatment.
- The use of PrEP is mentioned as a preventative measure against HIV, stressing that while it can enhance sexual health, consistent condom usage remains vital for STD prevention.
: Temperature-sensitive (TS) mutants of TP53 are thermally unstable, unfolded, and inactive at body temperature but can be refolded and reactivated at sub-physiological temperatures. TS TP53 may be amenable for functional rescue by hypothermia or structure-stabilizing drugs, and may retain low-level transcriptional activity at 37 °C. TP53 mutations are observed in 47% of all esophageal cancers (ECs) and 25% to 40% of gastric cancers (GCs).
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