Publications by authors named "A M Valles"
Article Synopsis
- - Recombinant adeno-associated virus (rAAV) gene therapies have great potential for treating various genetic disorders, requiring ongoing innovation in their development.
- - The novel miQURE technology utilizes microRNAs to target and silence toxic genes, and has evolved into the linQURE platform, which allows for simultaneous control of multiple gene expressions.
- - By demonstrating the capability to express two synthetic miRNAs together, linQURE enhances the effectiveness of gene therapy for complex diseases with multiple genetic contributors, ultimately broadening treatment options.
Germline cells produce gametes, which are specialized cells essential for sexual reproduction. Germline cells first amplify through several rounds of mitosis before switching to the meiotic program, which requires specific sets of proteins for DNA recombination, chromosome pairing, and segregation. Surprisingly, we previously found that some proteins of the synaptonemal complex, a prophase I meiotic structure, are already expressed and required in the mitotic region of Drosophila females.
View Article and Find Full Text PDFHuntington's disease (HD) is a fatal neurodegenerative disease caused by a trinucleotide repeat expansion in exon 1 of the huntingtin gene (HTT) that results in toxic gain of function and cell death. Despite its monogenic cause, the pathogenesis of HD is highly complex, and increasing evidence indicates that, in addition to the full-length (FL) mutant HTT protein, the expanded exon 1 HTT (HTTexon1) protein that is translated from the HTT1a transcript generated by aberrant splicing is prone to aggregate and might contribute to HD pathology. This finding suggests that reducing the expression of HTT1a might achieve a greater therapeutic benefit than targeting only FL mutant HTT.
View Article and Find Full Text PDFIn Brief: The endocrine disruptor, nonylphenol (NP) increases 20:4n-6 release in Sertoli cells via PKA/cPLA2 activation. Our data show that lipid metabolism could be a target of NP-induced abnormal reproductive outcomes.
Abstract: Nonylphenol (NP), an endocrine-disrupting chemical, is an environmental contaminant, and many notorious effects on male fertility have been reported in animal models and wild-type species.