The role of tumor-infiltrating lymphocytes (TILs) as a predictive biomarker of response to anti-PD1 therapy in patients with metastatic non-small cell lung cancer or metastatic melanoma.

Immunotherapy plays an important role in cancer treatment. Biomarkers that can predict response, including tumor-infiltrating lymphocytes (TILs), are in the spotlight of many studies. This cohort study was designed to evaluate the role of CD4+ and CD8+ TILs as predictive factors for response to anti PD-1 treatment in patients with metastatic non-small cell lung cancer (NSCLC) or metastatic melanoma.

[ROLE OF TGFβ-INDUCTION AND GASTROINTESTINAL MYOFIBROBLASTS IN PATHOMORPHOGENESIS OF CHRONIC GASTRITIS IN PATIENTS WITH MARFAN SYNDROME AND MARFAN-LIKE STATES].

Aim: The aim was to explore the features of epithelial morphogenesis and reparation of gastric mucosa in chronic gastritis in patients with Marfan syndrome and Marfan -like states.

Materials And Methods: A histological evaluation and immunohistochemical analysis of the expression of antibodies against α-actin smooth muscle (α-SMA), collagen type III and transforming growth factor β (TGFβ) in the gastric mucosa in 50 patients with hereditary disorders of connective tissue between the ages of 17 to 41 years were performed.

Results: In patients with Marfan syndrome and marfan-like states chronic gastritis was an unfavorable factor for the progression of the background atrophic and fibrotic processes in the gastric mucosa.

Post-irradiation angiosarcoma of the breast: clinical presentation and outcome in a series of six cases.

Angiosarcoma of the breast represents 1% of all soft tissue breast tumors. With breast-conserving therapy (BCT) as standard in the last three decades, a new type of angiosarcoma has been reported: post-irradiation angiosarcoma (PIAS). A recent study based on the SEER database found an absolute risk for PIAS of seven per 100,000 person-years for BCT patients.