Publications by authors named "A M Tokumaru"
Clin Neuropsychol
December 2024
Article Synopsis
- A case study focused on a 71-year-old woman with right temporal variant frontotemporal dementia (rtvFTD) revealed significant heading disorientation, showing that neurodegenerative diseases might impact spatial navigation differently than cerebrovascular diseases.
- Despite preserved general cognition, the patient struggled with familiar environments, unable to draw routes or maps, although she recognized landmarks; neuropsychological tests indicated specific heading disorientation related to her condition.
- Imaging studies (MRI and PET) showed notable abnormalities in the right hemisphere, especially in the retrosplenial region, which is linked to heading disorientation, and the patient’s symptoms worsened over time, which is distinct from prior observations with cerebrovascular cases.
Clin Park Relat Disord
October 2024
Article Synopsis
- A multicenter study in Japan began in 2014 to gather data on progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD) to better understand their clinical features and identify potential biomarkers.
- Initial assessments of 349 patients focused on symptoms, clinical scores (like the PSPRS), and factors affecting disease progression over eight years.
- Results indicated that patients with Richardson's syndrome (RS) had better clinical scores compared to those with CBD, and cognitive dysfunction played a significant role in disease severity and progression.
eNeurologicalSci
December 2024
Article Synopsis
- A 72-year-old man experienced a 6-month decline in voluntary speech marked by sparse speech and decreased word fluency, while other language abilities remained intact, indicating dynamic aphasia.
- Brain MRI showed left-sided white matter volume reduction in the frontal lobe, specifically affecting areas linked to speech production, and the patient's condition worsened over two years leading to complete mutism and death from aspiration pneumonia.
- The neuropathological diagnosis was corticobasal degeneration (CBD), suggesting that early signs of CBD may manifest as dynamic aphasia, potentially due to early involvement of certain brain pathways.
Neuroradiology
November 2024
Article Synopsis
- - The study investigates how well conventional MRI can differentiate corticobasal degeneration (CBD) from its mimics due to similar clinical features.
- - Researchers analyzed the degree of brain atrophy and asymmetry in MRI images of 19 CBD patients and 16 patients with conditions that mimic CBD, like Alzheimer's and progressive supranuclear palsy.
- - Findings suggest that specific patterns of atrophy and the presence of white matter hyperintensity can be used as imaging biomarkers to help diagnose CBD more accurately.
