Publications by authors named "A M Teper"
Article Synopsis
- The study investigates the genetic factors linked to severe COVID-19, specifically focusing on hospitalized cases in admixed Americans.
- Researchers conducted the largest genome-wide association study (GWAS) for COVID-19 hospitalization in this population, identifying four significant genetic associations, including two novel loci found in Latin Americans.
- The findings highlight the importance of including diverse populations in genomic research, aiming to improve understanding of genetic risks associated with COVID-19 across different ethnic groups.
Introduction: Brensocatib is an investigational, oral, reversible inhibitor of dipeptidyl peptidase-1 shown to prolong time to first exacerbation in adults with bronchiectasis. Outlined here are the clinical trial design, and baseline characteristics and treatment patterns of adult patients enrolled in the phase 3 ASPEN trial (NCT04594369).
Methods: The ASPEN trial is a global study enrolling patients with a clinical history consistent with bronchiectasis (cough, chronic sputum production and/or recurrent respiratory infections), diagnosis confirmed radiologically and ≥2 exacerbations in the prior 12 months.
Article Synopsis
- Cystic fibrosis (CF) is the most common autosomal recessive disorder in Caucasians, caused by mutations in the CFTR gene leading to protein dysfunction; CFTR modulators like lumacaftor-ivacaftor can improve cell surface CFTR activity.
- An analysis of 30 CF patients homozygous for the Phe508del mutation revealed that after 12 months of treatment, sweat chloride levels and body mass index (BMI) improved, along with reduced pulmonary exacerbations.
- The study showed promising results, with many patients experiencing a decrease in sputum production and improvement in breathing difficulties, indicating that the treatment has beneficial real-life effects.
Postinfectious bronchiolitis obliterans (PiBO) is a rare and severe form of chronic obstructive lung disease caused by an infectious injury to the lower respiratory tract. The most commonly recognized inciting stimuli leading to PiBO are airway pathogens, such as adenovirus and Mycoplasma. PiBO is characterized by persistent and nonreversible airway obstruction, with functional and radiological evidence of small airway involvement.
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