Publications by authors named "A M Ten"
Background: Patients with multiple sclerosis (MS) may remain in a relapsing-remitting (RRMS) course despite long-standing disease, while others will develop secondary progression (SPMS). Chronic inflammation and changes in the blood-brain barrier resulting in perturbed glucose metabolism may account for these differences. PET-MRI with kinetic analysis of 2-deoxy-2(18 F)fluoro-d-glucose (18 F-FDG) provides insight into glucose metabolism and has proven useful in several chronic inflammatory diseases.
View Article and Find Full Text PDFArticle Synopsis
- Membrane-associated 70 kDa heat shock protein (mHsp70) plays a crucial role in the migration and invasion of malignant brain tumor cells, as observed in patient samples.
- Advanced techniques like inverted confocal microscopy and mass spectrometry showed that mHsp70 is prominently expressed on the surface of cancer cells, particularly in areas surrounding the tumors.
- Inhibiting HSP70 with small molecules significantly reduced cancer cell invasiveness and delayed tumor progression in animal models, suggesting that targeting mHsp70 could be a promising strategy for developing new cancer therapies.
Nanostructures of some metals can sustain localized surface plasmon resonances, collective oscillations of free electrons excited by incident light. This effect results in wavelength-dependent absorption and scattering, enhancement of the incident electric field at the metal surface, and generation of hot carriers as a decay product. The enhanced electric field can be utilized to amplify the spectroscopic signal in surface-enhanced Raman scattering (SERS), while hot carriers can be exploited for catalytic applications.
View Article and Find Full Text PDFPrevious research suggests that curiosity is sometimes induced by novel information one has no relevant knowledge about, but it is sometimes induced by new information about something that one is familiar with and has prior knowledge about. However, the conditions under which novelty or familiarity triggers curiosity remain unclear. Using metacognitive confidence judgments as a proxy to quantify the amount of knowledge, this study evaluates the relationship between the amount of relevant knowledge and curiosity.
View Article and Find Full Text PDF