Publications by authors named "A M Tassin"
FacioScapuloHumeral muscular Dystrophy (FSHD) is one of the most prevalent inherited muscle disorders and is linked to the inappropriate expression of the DUX4 transcription factor in skeletal muscles. The deregulated molecular network causing FSHD muscle dysfunction and pathology is not well understood. It has been shown that the hypoxia response factor HIF1α is critically disturbed in FSHD and has a major role in DUX4-induced cell death.
View Article and Find Full Text PDFBackground: The benefits of friendships among peers with and without intellectual and developmental disabilities are well supported by research. However, little is known about the nature of these inclusive friendships in inclusive college courses.
Method: We explored the perspectives of peers on the development of authentic friendships among peers with and without intellectual and developmental disabilities in inclusive college courses in the United States.
Background: Hypoxia is known to modify skeletal muscle biological functions and muscle regeneration. However, the mechanisms underlying the effects of hypoxia on human myoblast differentiation remain unclear. The hypoxic response pathway is of particular interest in patients with hereditary muscular dystrophies since many present respiratory impairment and muscle regeneration defects.
View Article and Find Full Text PDFArticle Synopsis
- The centrosome is crucial for cell organization, stability, and the formation of cilia, and recent findings indicate it might also be involved in local protein synthesis.
- Researchers discovered that TDP-43, an RNA-binding protein linked to neurodegenerative diseases, is localized at the centrosome throughout the cell cycle, which was confirmed through advanced imaging techniques.
- The study identifies TDP-43's interaction with centrosomal mRNAs and proteins, suggesting that its dysfunction in the centrosome may play a role in the neurodegenerative processes associated with TDP-43-related diseases.