[Atypical antipsychotics in the treatment of depression in affective disorders and schizophrenia (using the aripiprazole model)].

The review discusses aspects of the use of atypical antipsychotics in the treatment of depression in affective disorders and schizophrenia using the model of aripiprazole, a partial agonist of dopamine receptors. According to numerous studies, aripiprazole is the drug of choice for augmentative therapy of major depressive disorder, as well as for relieving and long-term maintenance monotherapy and combination therapy of various affective episodes of bipolar affective disorder and depression in schizophrenia.

[ROS induction and structural modification in human lymphocyte membrane under the influence of carbon nanotubes].

To assess the potential risks of using the artificial nanostructures the structural state of the human lymphocyte membrane and lipid peroxidation under the influence of multi-walled carbon nanotubes with metal impurities was studied. The ability of carbon nanotubes to induce the formation of reactive oxygen species in cells was examined. A dose-dependent increase in reactive oxygen species formation in lymphocytes, which was not registered in cells pre-incubated with N-acetylcystein, after exposure to carbon nanotubes was shown.

[Morphometric analysis of the motor analyzer structures in albino and gray rats].

Cellular content of neuron populations of cortex, subcortical structures of brain and cerebellum and nuclei of anterior horns of cervical region of the spinal cord was studied in albino and grey rats. The revealed distinctive features of the tinctorial properties and sizes of neurons of different structures of the motor analyser are explained as an adaptation peculiarities of the animal brain organization. Heterogeneity of neuron population at different levels of the brain motor system indicates the different adaptation mechanisms of albino and grey rats.