Publications by authors named "A M Squire"
Background: Digital technologies can assess the quality of medicines in resource-challenged health facilities in a timely manner and ensure effective healthcare.
Objectives: This study assessed the quality of some non-communicable disease medicines, antimalarials, antibiotics, non-steroidal anti-inflammatory drugs and hematinics in selected healthcare facilities as part of their (potential) participation in a digital pharmaceutical supply chain management system (Med4All).
Methods: All the sampled medicines were screened using TruScan analyzer and GPHF-minilab, that is low-medium field technologies.
Article Synopsis
- Recent advances in light-sheet microscopy now allow for 3D analysis of microvascular networks in brain tissue without the need for histological sectioning, which was previously a barrier.
- In a study involving mice after a stroke model, researchers observed significant changes in microvessels over time, including an initial loss followed by a reemergence and increased complexity of small microvessels within 56 days.
- The administration of FTY720 (Fingolimod) after ischemia enhanced the growth and branching of small microvessels, highlighting its potential in improving microvascular architecture following a stroke.
Article Synopsis
- The report examines clinical, genetic, and biochemical characteristics of individuals with a confirmed congenital disorder of glycosylation (CDG) participating in the FCDGC Natural History cohort after five years of study.
- A total of 333 subjects were enrolled, with 280 having available genetic data; this included a nearly even split between males and females, with ages ranging from infancy to 71 years.
- The study found developmental delays to be the most common symptom leading to diagnosis, occurring in 77% of participants, with an average delay of 2.7 years from symptom onset to diagnosis, and nearly all individuals displaying some developmental differences at the time of enrollment.
Microvascular Network Remodeling in the Ischemic Mouse Brain Defined by Light Sheet Microscopy.
Arterioscler Thromb Vasc Biol
April 2024
Background: Until now, the analysis of microvascular networks in the reperfused ischemic brain has been limited due to tissue transparency challenges.
Methods: Using light sheet microscopy, we assessed microvascular network remodeling in the striatum from 3 hours to 56 days post-ischemia in 2 mouse models of transient middle cerebral artery occlusion lasting 20 or 40 minutes, resulting in mild ischemic brain injury or brain infarction, respectively. We also examined the effect of a clinically applicable S1P (sphingosine-1-phosphate) analog, FTY720 (fingolimod), on microvascular network remodeling.
The digestion of protein into peptide fragments reduces the size and complexity of protein molecules. Peptide fragments can be analyzed with higher sensitivity (often > 10 fold) and resolution using MALDI-TOF mass spectrometers, leading to improved pattern recognition by common machine learning algorithms. In turn, enhanced sensitivity and specificity for bacterial sorting and/or disease diagnosis may be obtained.
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