Interplay between JAK/STAT pathway and non-coding RNAs in different cancers.

Progress in the identification of core multi-protein modules within JAK/STAT pathway has enabled researchers to develop a better understanding of the linchpin role of deregulated signaling cascade in carcinogenesis and metastasis. More excitingly, complex interplay between JAK/STAT pathway and non-coding RNAs has been shown to reprogramme the outcome of signaling cascade and modulate immunological responses within tumor microenvironment. Wealth of information has comprehensively illustrated that most of this complexity regulates the re-shaping of the immunological responses.

Unraveling the Complex Web of Mechanistic Regulation of Versatile NEDD4 Family by Non-Coding RNAs in Carcinogenesis and Metastasis: From Cell Culture Studies to Animal Models.

Discoveries related to an intriguing feature of ubiquitination have prompted a detailed analysis of the ubiquitination patterns in malignant cells. How the "ubiquitinome" is reshaped during multistage carcinogenesis has garnered significant attention. Seminal studies related to the structural and functional characterization of NEDD4 (Neuronal precursor cell-expressed developmentally downregulated-4) have consolidated our understanding at a new level of maturity.

Correlation of radio and gamma emissions in lightning initiation.

The results of simultaneous radio and gamma emission measurements during thunderstorms are presented. A gamma detector situated at the height 3840 m and two radio detectors of Tien-Shan Mountain Scientific Station (altitude 3340 m) registered intensive gamma flashes and radio pulses during the time of lightning initiation. The radio-gamma correlation grows abruptly at the initial moment (a few hundred microseconds), and the correlation coefficient reaches 0.

Strong flux of low-energy neutrons produced by thunderstorms.

We report here for the first time about the registration of an extraordinary high flux of low-energy neutrons generated during thunderstorms. The measured neutron count rate enhancements are directly connected with thunderstorm discharges. The low-energy neutron flux value obtained in our work is a challenge for the photonuclear channel of neutron generation in thunderstorm: the estimated value of the needed high-energy γ-ray flux is about 3 orders of magnitude higher than that one observed.

[The effect of pancreatic islet cell implantation on the course of diabetic nephropathy].

The influence of the implanted allo- and xenocultures of the pancreas islet cells upon the course of nephropathy was studied in 61 patients with insulin-dependent diabetes mellitus. These cells were found to have a positive influence upon the functional state of the kidneys in patients with diabetic nephropathy especially at its initial stage.