Publications by authors named "A M Schrader"

Background: With over 65,000 new cases per year in Germany, prostate cancer (PC) is the most common cancer in men in Germany. Localized PC is often treated by radical prostatectomy and has a very good prognosis. Postoperative quality of life (QoL) is significantly influenced by the side effects of surgery.

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In our study, the post-radiotherapy quality of life of prostate cancer patients who previously underwent transurethral resection of the prostate (TURP) is compared to those who had thulium laser enucleation of the prostate (ThuLEP) and those who had no prior surgery. It also aims to identify and assess risk factors affecting therapy tolerance in this patient group. We analyzed 132 patients with localized prostate cancer treated with definitive radiotherapy (RT), including 23 who had prior TURP and 19 who previously underwent ThuLEP.

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Article Synopsis
  • Cisplatin, a chemotherapy drug, leads to irreversible hearing loss by damaging cochlear hair cells, with mitochondrial activity playing a crucial role in this process.
  • * Researchers used zebrafish to show that increased redox history heightens hair cell vulnerability to cisplatin, and observed significant changes in mitochondrial and calcium levels before hair cell death.
  • * The study found that cisplatin accumulates specifically in hair cell mitochondria prior to causing mitochondrial dysfunction, highlighting the mitochondria's essential role in the drug's toxic effects.*
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