Publications by authors named "A M Scanu"
: Although treatments using thermal water have yielded beneficial effects in respiratory tract infections, the effects of thermal water under experimental conditions similar to those triggered by SARS-CoV-2 have yet to be evaluated. This study aimed to assess whether thermal water could interfere with the interaction between SARS-CoV-2 and host cells and influence inflammatory factors. : Human nasal epithelial primary cells (HNEpCs) were stimulated with SARS-CoV-2 spike protein in the presence or absence of thermal water or tap water.
View Article and Find Full Text PDFArticle Synopsis
- The review discusses the long-understood but poorly defined pathogenesis of calcium pyrophosphate deposition (CPPD), highlighting the need for deeper research.
- Recent advancements include the 2023 ACR/EULAR classification criteria for CPPD and new imaging techniques, although basic research is lagging behind.
- Emerging methods like Raman spectroscopy and omics sciences may pave the way for better understanding and management of CPPD as it becomes more common in an aging population.
Article Synopsis
- Accumulating senescent cells contribute to aging and diseases, prompting research into botanical extracts for potential therapies that could target these issues.
- A standardized extract of Salvia haenkei (HK) was found to extend both lifespan and healthspan in aged mice by reducing inflammation and markers of senescence while improving muscle strength and fur quality.
- The study identified luteolin, a flavonoid in HK, as a compound that disrupts the interaction between the proteins p16 and CDK6, suggesting a mechanism through which HK promotes longevity by modulating cellular senescence.
The translational value of calcium pyrophosphate deposition disease experimental mouse models.
Front Med (Lausanne)
May 2024
Article Synopsis
- The deposition of calcium pyrophosphate (CPP) crystals in joints causes arthritis, particularly in older adults, leading to acute and chronic pain.
- Experimental models for studying CPPD are either genetically modified or crystal-induced inflammation, with the latter being more effective in mimicking human conditions.
- While these models are essential for understanding CPPD and testing treatments, they are still in early development and require significant improvements for better translational outcomes.