Publications by authors named "A M Saracino"
Background: BICSTaR is a multi-national, observational cohort evaluating the effectiveness, safety, and patient-reported outcomes (PROs) in treatment-naïve (TN) and -experienced (TE) people with HIV-1 receiving bictegravir/emtricitabine/tenofovir alafenamide (B/F/TAF) in routine clinical care. We present the 12-month (M12) outcomes of the Italian BICSTaR cohort.
Methods: Participants initiating B/F/TAF in routine care were prospectively followed.
Comparative effectiveness of chest ultrasound, chest X-ray and computer-aided diagnostic (CAD) for tuberculosis diagnosis in low-resource setting: study protocol for a cross-sectional study from Ethiopia.
Front Public Health
December 2024
Predictors for choosing doravirine-based versus INSTI-based regimen in ART-naïve and ART-experienced people with HIV in real-world setting: Data from the Icona cohort.
HIV Med
December 2024
Rationale: Doravirine (DOR) is an attractive new option both for ART-naïve people with HIV (PWH) and those with suppressed HIV-RNA who seek treatment simplification. We used real-world data to examine the pattern of use of DOR-containing regimens in these settings.
Methods: All PWH enrolled in the Icona cohort after January 2020 who initiated a three-drug regimen (3-DR) with DOR or an integrase inhibitor (INSTI)-based regimen as first antiretroviral therapy (ART) or when switching ART, with HIV-RNA ≤50 copies/mL, were included.
Article Synopsis
- Climate change is causing more frequent and intense tropical cyclones in Mozambique, leading to health crises like cholera outbreaks, particularly after Cyclones Idai and Kenneth in 2019.
- A study in Cabo Delgado Province investigated factors contributing to acute watery diarrhea (AWD) and cholera, surveying 1,615 households to analyze the impact of climate disasters and armed conflict on health.
- Key risk factors identified included overcrowding, poor access to safe water, and inadequate handwashing facilities, highlighting the need for targeted climate adaptation policies to improve community health.
Article Synopsis
- Long COVID is a significant public health issue affecting many individuals, with this study aiming to identify predictors of its development and specific symptoms over time.
- The study involved over 1,000 hospitalized COVID-19 patients in Italy, using structured phone questionnaires to assess long COVID incidence and symptoms after a median follow-up of 19 months.
- Results indicated that 91.7% experienced long COVID, particularly affecting respiratory and neurological systems, with vaccination reducing symptom odds and Delta variant infection greatly increasing the risk for neuropsychiatric symptoms.