Publications by authors named "A M Santilli"
Susceptibility to and severity of pulmonary infections increase with ethanol consumption. We have previously shown that ethanol-induced changes in the gut microbiome disrupt gut homeostasis, allowing for the translocation of proinflammatory mediators into the circulation and eliciting an immune response in the lung. Additionally, targeting the gut with butyrate supplementation not only rescues ethanol-induced disruptions to gut health but also reverses aspects of immune dysregulation in the lungs.
View Article and Find Full Text PDFArticle Synopsis
- - This study introduces a new type of autoimmune myopathy called immune-mediated megaconial myopathy (IMMM), which is recognized by the presence of giant mitochondria in muscle tissue.
- - Researchers analyzed data from the Mayo Clinic to identify five patients with cases of IMMM, who displayed symptoms like progressive muscle weakness, high creatine kinase levels, and specific muscle fiber characteristics.
- - Treatment with immunomodulatory therapy showed improvements in most patients, and interestingly, all of them had simultaneous pancreatic diseases, suggesting a possible link that requires further investigation.
Objective: To evaluate the viability of the vaginal route as an alternative to laparoscopy for patients seeking permanent surgical contraception.
Methods: We conducted a retrospective cohort study in 2021, dividing patients into two groups based on their preference: vaginal and laparoscopic salpingectomy. The statistical analysis was conducted using STATA, employing standard statistical methods based on the distribution of variables.
Excessive alcohol consumption increases the severity and worsens outcomes of pulmonary infections, often due to oxidative stress and tissue damage. While the mechanism behind this relationship is multifaceted, recent evidence suggests ethanol-induced changes to the gut microbiome impact the gut-lung axis. To assess this, a chronic-binge ethanol feeding mouse model was used to determine how ethanol altered the gut microbiome, small intestinal epithelial barrier, and immune responses, as well as neutrophil abundance and oxidative stress in the lungs, and how supporting gut health with tributyrin supplementation during chronic-binge ethanol exposure affected these responses.
View Article and Find Full Text PDFIntroduction/aims: Femoral neuropathies can cause severe, prolonged debility, yet there have been few clinical and electrodiagnostic (EDx) studies addressing this condition. The aim of this study was to better understand the etiologies, EDx features, and clinical course of femoral neuropathy.
Methods: We identified patients evaluated at Mayo Clinic Rochester between January 1, 1999 and July 31, 2019, with possible new femoral neuropathy ascertained via International Classification of Diseases-versions 9 and 10 diagnosis codes presenting within 6 months of symptom onset.