Preoperative planning to preserve glenoid subchondral bone in anatomical total shoulder replacement.

Background: Glenoid loosening remains a concern in anatomical total shoulder replacement. Preoperative planning software allows optimization of the component positioning, but the target orientation remains unclear due to conflicting optimization priorities. Commonly, the component is aligned to the prescribed version and inclination that reflect the population's average anatomy.

Single-cell dissection of aggression in honeybee colonies.

Understanding how genotypic variation results in phenotypic variation is especially difficult for collective behaviour because group phenotypes arise from complex interactions among group members. A genome-wide association study identified hundreds of genes associated with colony-level variation in honeybee aggression, many of which also showed strong signals of positive selection, but the influence of these 'colony aggression genes' on brain function was unknown. Here we use single-cell (sc) transcriptomics and gene regulatory network (GRN) analyses to test the hypothesis that genetic variation for colony aggression influences individual differences in brain gene expression and/or gene regulation.

Single-Pass Albumin Dialysis as Rescue Therapy for Pediatric Calcium Channel Blocker Overdose.

Calcium channel blocker ingestions remain one of the leading causes of death related to cardiovascular medication ingestion in both adults and pediatric patients. We report a case of a 17-year-old, 103 kg female presenting after an intentional polypharmacy ingestion, including 500 to 550 mg of amlodipine. She presented with profound vasoplegia and cardiovascular collapse requiring high-dose inotropes and eventual life support with extracorporeal membrane oxygenation (ECMO).

Shoulder examination: a systematic approach.

The shoulder is a complex joint with static and dynamic stabilising structures working synchronously. These allow a full range of movement while preserving stability of the joint. Patients may present with pain, stiffness, weakness, deformity or instability.

Neurodevelopmental and transcriptomic effects of CRISPR/Cas9-induced somatic mutation in honey bees.

In insects, odorant receptors facilitate olfactory communication and require the functionality of the highly conserved co-receptor gene . Genome editing studies in a few species of ants and moths have revealed that can also have a neurodevelopmental function, in addition to its canonical role in adult olfaction, discovered first in . To extend this analysis, we determined whether mutations also affect the development of the adult brain of the honey bee , an important model system for social behavior and chemical communication.