Publications by authors named "A M Samii"
Objective: Chronic subdural hematoma (CSDH) is frequently met in neurosurgical practice and often need urgent surgical treatment in case of neurological deterioration. Different surgical approaches to evacuate CSDH are described in the literature. In our experience, an external drainage system is crucial in order to avoid recurrences.
View Article and Find Full Text PDFBackground: The diverse and complex attributes of cancer have made it a daunting challenge to overcome globally and remains to endanger human life. Detection of critical cancer-related gene alterations in solid tumor samples better defines patient diagnosis and prognosis, and indicates what targeted therapies must be administered to improve cancer patients' outcome.
Materials And Methods: To identify genes that have aberrant expression across different cancer types, differential expressed genes were detected within the TCGA datasets.
Retrosigmoid Intradural Suprameatal Approach: 2-Dimensional Operative Video.
Oper Neurosurg (Hagerstown)
December 2023
Indications Corridor And Limits Of Exposure: The retrosigmoid intradural suprameatal approach is mostly indicated for tumors in the cerebellopontine angle extending toward the Meckel cave and supratentorial regions, most frequently meningiomas and schwannomas. This approach was first established by the senior author in 1982.
Anatomic Essentials Need For Preoperative Planning And Assessment: Nervous structures: cranial nerves III to XII, cerebellum, and brainstem.
Background: This meta-analysis aimed to provide a comprehensive assessment of the association between Methylenetetrahydrofolate reductase () gene polymorphisms, specifically C677T and A1298C, and the susceptibility to myocardial infarction (MI).
Methods: A systematic literature search was conducted in MEDLINE, Web of Science, and Scopus until April 2023 to identify studies investigating the relationship between gene polymorphisms (C677T and A1298C) and the risk of MI.
Results: The analysis included 66 studies involving 16,860 cases and 20,403 controls for the C677T polymorphism and 18 studies comprising 3162 cases and 3632 controls for the A1298C polymorphism.
Article Synopsis
- Pathogenic variants in the POLE and POLD1 genes are linked to an inherited condition, polymerase proofreading-associated polyposis, which increases the risk of colorectal cancer and other tumors, including gliomas.
- Whole-exome sequencing of glioma patients revealed that 16% carried rare deleterious POLE/POLD1 variants, with significant features indicating defective DNA proofreading and a correlation with tumor characteristics.
- Glioblastoma patients with these variants had a notably shorter average overall survival of 21 months, and these genetic variants might also make glioma patients more responsive to immunotherapy and warrant ongoing surveillance for other cancer risks.