Publications by authors named "A M Sadykov"

Novel energetic materials (EM) often combine two intrinsically counter trends, , a high energy density and mediocre safety parameters, like thermal stability and sensitivity toward mechanical stimuli. A rational design of promising EMs requires a proper understanding of their thermal stability at both macroscopic and molecular levels. In the present contribution, we studied in detail the thermal stability of 4,4'-dinitro-3,3'-diazenofuroxan (DDF), an ultrahigh-performance energetic material with a reliable experimental detonation velocity being very close to 10 km s.

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We studied the effect of the α-adrenergic receptor agonist clonidine hydrochloride (10-10 M) on the isolated heart of adult rats after 30-day restriction of motor activity. In hypokinetic rats, in comparison with control animals, clonidine caused a positive inotropic effect; the dynamics of coronary flow was changed after stimulation of α-adrenergic receptors by clonidine in the minimum and maximum concentrations. Moreover, clonidine in concentrations of 10 and 10 M reduced coronary flow both in the control group and against the background of hypokinesia.

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Article Synopsis
  • The study investigates the early bone responses in mild chronic kidney disease (CKD) using hypertensive rats and looks at various biomarkers and histological changes.
  • It finds that despite mild CKD, certain systemic phosphate-regulating factors remained normal, yet there were significant changes in bone structure and gene expression.
  • Specifically, the research indicates a decline in osteoblast numbers and overall bone turnover, highlighting a potential maladaptive response of bones to CKD even at mild stages.
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Natural resources are in short supply, and the ecosystem is being damaged as a result of the overuse of fossil fuels. The creation of novel technology is greatly desired for investigating renewable and sustainable energy sources. Microorganisms have received a lot of interest recently for their potential to transform organic waste into sustainable energy and high-value goods.

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Background: Kivach Clinic has developed a special medical spa program to prevent aging-related conditions in metabolic, cardio-vascular, and neurological states. Spa programs modify diet, physical activity, and lymphatic drainage, as it deteriorates with aging. We investigated its influence on the blood markers of biological age of patients during their stay to objectify the potential of spa treatment for influencing the risk of age-related events.

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