Publications by authors named "A M Rudolf"

Fungal bioluminescence is mystifying humans since ancient times. Nevertheless, the biosynthetic pathway behind this phenomenon was only very recently resolved. Fungal bioluminescence occurs in five distantly related linages ( lineage, lineage, mycenoid lineage, Lucentipes lineage and lineage) of the basidiomycete order .

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  • Twisted gastrulation (TWSG1) is a key protein that regulates Bone Morphogenetic Protein (BMP) signaling, which is important for various biological processes like embryonic development, kidney regeneration, and cancer.
  • Researchers determined the crystal structures of TWSG1 both alone and with a BMP ligand, illustrating how TWSG1's distinct domains interact with BMPs and their antagonist Chordin.
  • TWSG1 inhibits BMP signaling in lab experiments, and mutations affecting its BMP-binding ability disrupt this inhibition, demonstrating the crucial role of TWSG1 in regulating BMP activity and its evolutionary conservation across species.
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Maternal overnutrition during lactation predisposes offspring to develop metabolic diseases and exacerbates the relevant syndromes in males more than females in later life. The hypothalamus is a heterogenous brain region that regulates energy balance. Here we combined metabolic trait quantification of mother and offspring mice under low and high fat diet (HFD) feeding during lactation, with single nucleus transcriptomic profiling of their offspring hypothalamus at peak lacation to understand the cellular and molecular alterations in response to maternal dietary pertubation.

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Space is a challenging environment that deregulates individual homeostasis. The main external hazards associated with spaceflight include ionizing space radiation, microgravity, isolation and confinement, distance from Earth, and hostile environment. Characterizing the biological responses to spaceflight environment is essential to validate the health risks, and to develop effective protection strategies.

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Background: Mobile health (mHealth) apps show vast potential in supporting patients and health care systems with the increasing prevalence and economic costs of noncommunicable diseases (NCDs) worldwide. However, despite the availability of evidence-based mHealth apps, a substantial proportion of users do not adhere to them as intended and may consequently not receive treatment. Therefore, understanding the factors that act as barriers to or facilitators of adherence is a fundamental concern in preventing intervention dropouts and increasing the effectiveness of digital health interventions.

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