Publications by authors named "A M Pouta"
Article Synopsis
- Gestational diabetes mellitus (GDM) is identified through abnormal results in an oral glucose tolerance test (OGTT), with a lack of clear understanding about how the number of abnormal values relates to negative birth outcomes.
- A study involving 4869 pregnant women in Finland analyzed the connection between the quantity of abnormal OGTT values and adverse perinatal and neonatal results, taking into account various health and social factors.
- Results indicated that women with two or more abnormal OGTT values had significantly higher rates of negative perinatal (35.0% vs. 27.5%) and neonatal outcomes (31.1% vs. 18.9%) compared to those with fewer or no abnormal values.
Article Synopsis
- Scientists looked at the timing of when girls start their periods (called menarche) and how it can affect their health later in life.
- They studied about 800,000 women and found over a thousand genetic signals that influence when menstruation starts.
- Some women have a much higher chance of starting their periods too early or too late based on their genetic makeup, suggesting that genes play a big role in this process!
Background: Gestational diabetes mellitus (GDM) is a common pregnancy-related disorder and a well-known risk factor for adverse pregnancy outcomes. There are conflicting findings on the association of GDM with the risk of congenital anomalies (CAs) in offspring. In this study, we aimed to determine study whether maternal GDM is associated with an increased risk of major CAs in offspring.
View Article and Find Full Text PDFPubertal timing varies considerably and has been associated with a range of health outcomes in later life. To elucidate the underlying biological mechanisms, we performed multi-ancestry genetic analyses in ~800,000 women, identifying 1,080 independent signals associated with age at menarche. Collectively these loci explained 11% of the trait variance in an independent sample, with women at the top and bottom 1% of polygenic risk exhibiting a ~11 and ~14-fold higher risk of delayed and precocious pubertal development, respectively.
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