PurposeChimeric antigen receptor (CAR) T-cell CD19 therapy has changed the treatment paradigm for patients with relapsed/refractory B-cell acute lymphoblastic leukemia. It is frequently associated with potentially severe toxicities: cytokine release syndrome (CRS) and immune effector cell-associated neurotoxicity syndrome (ICANS), and admission to PICU is often required. Some biomarkers seem to correlate with CRS severity.
View Article and Find Full Text PDFBackground: Centrifugal compressors are dynamic machines utilizing a rotating impeller, efficiently accelerate incoming gases, transforming kinetic energy into pressure energy for compression. They serve a wide range of industries, including air conditioning, refrigeration, gas turbines, industrial processes, and applications such as air compression, gas transportation, and petrochemicals, demonstrating their versatility. Designing a centrifugal compressor poses challenges related to achieving high aerodynamic efficiency, surge and choke control, material selection, rotor dynamics, cavitation, erosion, and addressing environmental considerations while balancing costs.
View Article and Find Full Text PDFHydroxyapatite (HA), the main inorganic bone component, is the most widely researched bioceramic for bone repair. This paper presents a comprehensive review of recent advancements in HA synthesis methods and their integration into additive manufacturing (AM) processes. Synthesis methodologies discussed include wet, dry, and biomimetic routes, emphasizing their impact on tailoring the physicochemical properties of HA for biomedical applications.
View Article and Find Full Text PDFThis paper provides a thorough analysis of recent advancements and emerging trends in the integration of metal additive manufacturing (AM) within orthopedic implant development. With an emphasis on the use of various metals and alloys, including titanium, cobalt-chromium, and nickel-titanium, the review looks at their characteristics and how they relate to the creation of various orthopedic implants, such as spinal implants, hip and knee replacements, and cranial-facial reconstructions. The study highlights how metal additive manufacturing (AM) can revolutionize the field by enabling customized implant designs that take patient anatomical variances into account.
View Article and Find Full Text PDFPeriodontitis is complex microbial plaque induced condition. In this study, HiOra herbal mouthwash widely marketed in India, achieved a 5-log reduction in standard fungi and bacterial strains within 60 min. Thereby demonstrating antibacterial and antifungal activity similar to chlorhexidine and accordance with the PN EN 1040 and EN 1650 standards.
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