Publications by authors named "A M Pico"
Introduction: Low back pain is common during pregnancy, affecting up to 76% of women. However, symptomatic lumbar disc herniation (LDH) is rare, occurring in about 1 in 10,000 pregnancies, with less than 2% progressing to cauda equina syndrome (CES). The overlap in symptoms between LDH and typical pregnancy-related conditions complicates both diagnosis and management.
View Article and Find Full Text PDFBackground: Idiopathic normal pressure hydrocephalus is classically recognized by the triad of gait disturbance, cognitive dysfunction, and urinary incontinence. Since ventricular shunting may be affected by valve type, we conducted a meta-analysis to assess the relationship between valve characteristics and outcomes.
Methods: English language studies that reported valve types, outcomes, and associated complications were included.
The HeartMate 3 risk score (HM3RS) was developed from the Multicenter Study of MagLev Technology in Patients Undergoing Mechanical Circulatory Support Therapy with HeartMate 3 (MOMENTUM 3) clinical trial to predict 1 and 2 year mortality after left ventricular assist device implantation. However, it has not been validated in a real-world population, especially after the heart transplant allocation system change on October 18, 2018. In this multicenter retrospective analysis, we found that HM3RS did not predict 1 and 2 year outcomes in the contemporary era, highlighting the need to revise this risk prediction tool in the real-world setting.
View Article and Find Full Text PDFArticle Synopsis
- Computer-vision and machine-learning techniques are being utilized to evaluate mouse behavior in Alzheimer's disease models, using a method called variational animal motion embedding (VAME).
- Significant changes in behavior were observed in Alzheimer’s models, such as age-related differences and increased randomness in actions.
- Intervention by blocking certain neuroinflammation processes largely mitigated these behavioral changes, highlighting the impact of neuroinflammation on spontaneous behavior in Alzheimer's disease.
Objective: To determine the preferences regarding injection, medication frequency and complexity of GLP1 receptor agonists among patients with type 2 diabetes, treatment-naïve for such drugs in Spain. Additionally, patients' willingness to pay according to these attributes was evaluated.
Methods: A discrete-choice experiment survey designed to evaluate patients' preferences over three attributes discriminating by age, sex and patients experience with previous injectable treatment was fulfilled by patients.