Publications by authors named "A M Perez-Castillo"
5-Methoxy-3-(5-methoxyindolin-2-yl)-1H-indole (3), whose structure was unambiguously elucidated by X-ray analysis, was identified as a multi-target compound with potential application in neurodegenerative diseases. It is a low nanomolar inhibitor of QR2 (IC = 7.7 nM), with greater potency than melatonin and comparable efficacy to the most potent QR2 inhibitors described to date.
View Article and Find Full Text PDFThe identification of Parkinson's disease (PD) biomarkers has become a main goal for the diagnosis of this neurodegenerative disorder. PD has not only been intrinsically related to neurological problems, but also to a series of alterations in peripheral metabolism. The purpose of this study was to identify metabolic changes in the liver in mouse models of PD with the scope of finding new peripheral biomarkers for PD diagnosis.
View Article and Find Full Text PDFArticle Synopsis
- Parkinson's disease (PD) is a neurodegenerative disorder linked to the loss of dopamine-producing neurons, and current treatments only manage symptoms, highlighting the need for new therapeutic targets.
- The transcription factor CCAAT/Enhancer Binding Protein β (C/EBPβ) shows altered levels in various neurodegenerative diseases, indicating its potential as a therapeutic target for PD, particularly in regulating genes like mitochondrial transcription factor A (TFAM).
- Research showed that overexpressing C/EBPβ enhances TFAM activity, while reducing C/EBPβ levels led to increased TFAM and other mitochondrial markers, suggesting a role of C/EBPβ in mitochondrial function and autophagy processes in PD.
Article Synopsis
- * Current research suggests that anticoagulant treatment may reduce the incidence of dementia in patients with conditions like atrial fibrillation, with direct oral anticoagulants showing the most promise.
- * There is a need for further research to determine how anticoagulation could serve as a preventative or therapeutic measure for AD, including identifying the most effective drugs and strategies with minimal risks.
Article Synopsis
- Astrocytomas are aggressive brain tumors, and this study explores the role of specific genetic variants (AGT, MGMT, TP53) in their prognosis, particularly in Mexican patients.
- Researchers sequenced DNA from 48 Mexican patients with astrocytoma to identify variants and compared the results to a larger dataset from The Cancer Genome Atlas.
- Findings revealed more AGT and MGMT variants in the Mexican cohort, with AGT variants only found in women, and both MGMT variations and promoter methylation linked to improved survival and chemotherapy response, suggesting distinct molecular profiles based on gender and population.