Publications by authors named "A M Peers"
The UK has fallen from fourth to 10th place in the global ranking for clinical trial activities in the past 6 years. Due to the limited capacity of the clinical trial pharmacy workforce and delays in providing pharmacy approvals, pharmacy has been identified as one of the constraining services that delays the set-up and delivery of clinical trials. To tackle this problem, we developed a single pharmacy review process for multicentre trials across Greater Manchester (GM) and tested its feasibility and implementation in our region.
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- The paper sequenced sheep interleukin 23A (p19) and found it shares high genetic similarity with IL23A from other species, including 98% with bovines and 85% with humans.
- It identified two variants of IL23A that differ notably in their signal sequence encoding region.
- The study used RT-qPCR to measure IL23A levels in sheep infected with Mycobacterium avium and Teladorsagia circumcincta, observing that higher IL23A levels correlate with inflammation but not with macrophage infiltration in certain forms of paratuberculosis.
Expressed gene sequences of two variants of sheep interleukin-25.
Vet Immunol Immunopathol
February 2011
This report describes the cloning and characterization of sheep interleukin-25 (IL25) expressed gene sequences and shows that, like humans, sheep express two transcript variants of IL25. Transcript variant 1 (IL25v1) has a 510 bp open reading frame encoding a 169 amino acid polypeptide with a calculated M(r) 19,200. The 498 bp IL25v2 encodes a 165 amino acid polypeptide with a calculated M(r) 18,710; both with an isoelectric point equal to 8.
View Article and Find Full Text PDFUnlabelled: Fumes produced during frying have been implicated as a potential cause for the increased incidence of adenocarcinoma. Particulate matter exposure has also been linked with other pulmonary and coronary disease. This study investigated the contribution of frying in residential settings to ultrafine and fine particulate matter (UFP, PM2.
View Article and Find Full Text PDFAim: To examine cardiovascular, hormonal and other physiological responses of 2-month-old lambs to rubber-ring castration and tail docking.
Methods: Twenty-two male lambs, well accustomed to handling and prepared with femoral artery and jugular vein cannulae, were studied during a 5 h control period and, at least 2 days later, for 1 h before and 4 h after castration and tail docking using rubber rings. Pressure recordings were made via femoral cannulae and blood samples for analysis of plasma constituents were taken from jugular cannulae.