Publications by authors named "A M Pawlowski"
Identifying immunosuppressed patients using structured data can be challenging. Large language models effectively extract structured concepts from unstructured clinical text. Here we show that GPT-4o outperforms traditional approaches in identifying immunosuppressive conditions and medication use by processing hospital admission notes.
View Article and Find Full Text PDFArticle Synopsis
- Angiotensin II (ATII) has been linked to higher thrombosis risk, but there's limited research on its effects in patients with mechanical circulatory support (MCS).
- This retrospective study analyzed adult patients in the cardiothoracic intensive care unit (CTICU) on temporary MCS between September 2018 and August 2022, comparing those who received ATII with a control group.
- While the study found that patients receiving ATII had numerically higher rates of thrombosis (41.5% vs 20.6%), the difference wasn't statistically significant, highlighting the need for more research on ATII's safety in MCS patients.
Eosinophilia and Adverse Effects of Dupilumab for Respiratory Indications: A Real-World Setting.
J Allergy Clin Immunol Pract
January 2025
Article Synopsis
- Dupilumab is effective for treating asthma and chronic rhinosinusitis with nasal polyps (CRSwNP), but can cause eosinophilia (high eosinophil counts) in some patients.
- In a study of 251 patients, 11.3% developed eosinophilia after starting dupilumab, but most experienced no significant adverse effects related to it.
- Despite the presence of eosinophilia, many patients still achieved significant treatment benefits, suggesting dupilumab remains a viable option for asthma and CRSwNP management.
Background: Antibiotic stewardship in critically ill pneumonia patients is crucial yet challenging, partly due to the limited diagnostic yield of noninvasive infectious tests. In this study, we report an antibiotic prescription pattern informed by bronchoalveolar lavage (BAL) results, where clinicians de-escalate antibiotics based on the combination of quantitative cultures and multiplex PCR rapid diagnostic tests.
Methods: We analyzed data from SCRIPT, a single-center prospective cohort study of mechanically ventilated patients who underwent a BAL for suspected pneumonia.