Publications by authors named "A M Orsi"
Purpose: This study reports the relationship between posterior cruciate ligament (PCL) retention vs resection and soft tissue laxity and balance throughout flexion using a robotically controlled ligament tensioner.
Methods: 55 robotic-assisted TKAs (Total knee arthroplasty) were retrospectively reviewe. The robotic ligament tensioner collected laxity data both before and after PCL resection.
: Three respiratory syncytial virus (RSV) vaccines have been recently made available for older adults. Understanding the principal characteristics of the first vaccine-takers can pave the way for a successful vaccination campaign. The objective of this study was to explore the sociodemographic and clinical characteristics of the first Italian users of an adjuvanted RSV vaccine and their attitudes towards RSV and vaccination.
View Article and Find Full Text PDFBackground: Data on the natural history of the community-acquired RSV in adult outpatients are limited. It is also unclear whether the existing influenza surveillance platforms based on influenza-like illness (ILI) case definitions are efficient for RSV. The two-season RESPIRA-50 study was established in 2023 to identify an optimal RSV case definition and to explore the natural history of RSV.
View Article and Find Full Text PDFArticle Synopsis
- - Polymeric IgM, an important immunoglobulin, has a strong ability to bind antigens and complements, primarily produced as hexamers or pentamers, with the latter containing a protein called the J-chain for enhanced transportation across cell layers.
- - The study reveals that the J-chain competes with the sixth subunit during IgM assembly and exists in an unstructured form before stabilizing pentamer formation through interactions with newly formed structures.
- - The process is regulated by a quality control factor known as ERp44, which ensures that only properly assembled IgM is secreted, thereby ensuring effective immune responses.
Background: Influenza can be associated with nonrespiratory disease presentation, but these are less well documented due to the lack of routine testing for influenza in the healthcare system, especially if patients do not present with influenza-like illness (ILI). We aimed to measure the proportion of influenza cases seeking care at emergency department (ED) for a nontraumatic cause, to describe their clinical presentation and their ED-discharge diagnosis.
Methods: The study was conducted at seven hospitals in France, Spain, Italy and Germany during the 2019-20 influenza season, for a period of 10 weeks.