Publications by authors named "A M Orlandi"
Background: Successful aging is associated with an increase in life expectancy. For a better understanding of the aging process, recognize the relationship between telomere length and nutritional status is a novel approach in geriatric science. Telomers shortening coincides with a decrease in life expectancy, and an increased risk of malnutrition-related diseases.
View Article and Find Full Text PDFIn the pathophysiology of osteoarthritis and osteoporosis, articular cartilage and bone represent the target tissues, respectively, but muscle is also involved. Since many changes in energy metabolism occur in muscle with aging, the aim of the present work was to investigate the involvement of carnitine palmitoyl transferase 1b (Cpt1b) in the muscle pathophysiology of the two diseases. Healthy subjects (CTR, = 5), osteoarthritic (OA, = 10), and osteoporotic (OP, = 10) patients were enrolled.
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- Emergency surgeries for bowel obstructions are challenging and often under-researched in terms of outcomes and risk factors.
- This study analyzed 99 patients to compare the rates of major postoperative complications between those with benign and cancer-related obstructions, finding a higher complication rate in cancer patients (41% vs. 20%).
- The KNN model was the most accurate in predicting complications, suggesting that using data-driven methods could enhance patient management for those undergoing emergency surgery for bowel obstruction.
Article Synopsis
- The study aimed to analyze attrition rates from first-line to third-line therapies in patients with HER2-positive metastatic breast cancer across several European countries.
- It found that 29.6% of patients discontinued treatment after first-line therapy and 34.2% after second-line therapy, often due to death or transition to palliative care.
- Additionally, the time patients remained on treatment decreased with each line of therapy, indicating diminishing effectiveness of subsequent treatments.