Publications by authors named "A M Orjuela"
Article Synopsis
- POCOP-Ni(II) pincer compounds, initially studied for their catalytic properties, were evaluated for their anticancer and antioxidant activities in this research.
- Four specific POCOP-Ni(II) complexes derived from phloroglucinol showed significant cytotoxicity against various cancer cell lines, with IC values between 2.43 and 7.85 μM.
- The study also employed techniques like single-crystal X-ray diffraction to analyze molecular structures and suggested that these complexes can intercalate with DNA, indicating potential mechanisms for their therapeutic effects.
Background: Carotenoids, potent antioxidants in fruits and vegetables, have recently garnered attention for their potential therapeutic effects against neurodegenerative diseases. This study focuses on the interaction and anti-aggregation properties of conventional and unconventional carotenoids found in red mamey fruit, a nutraceutical fruit that is a rich source of these compounds.
Objective: To assess computational the interaction between of amyloid-β (Aβ) peptide with a set of carotenoids and three carotenoids previously explored in experimental assays as well as to assess ADMET prediction of carotenoids selected by computational analysis results.
Article Synopsis
- The study compares the effectiveness and toxicity of two treatments, rituximab (RTX) and cyclophosphamide (CYC), for pediatric patients with granulomatosis with polyangiitis (GPA) and microscopic polyangiitis (MPA).
- It analyzes data from 104 patients and finds no significant difference in remission rates or severe adverse events between the two treatment groups.
- Limitations of the study include the lack of standardized treatment protocols and the retrospective nature of the analysis.
Background: Lupus nephritis (LN) is a very severe manifestation of lupus. There is no consensus on which treatment goals should be achieved to protect kidney function in children with LN.
Methods: We retrospectively analyzed trends of commonly used laboratory biomarkers of 428 patients (≤ 18 years old) with biopsy-proven LN class ≥ III.
Article Synopsis
- * A case report describes a 15-year-old male kidney transplant recipient who developed malakoplakia after experiencing recurrent diarrhea, confirmed through various tests and a colonoscopy.
- * The patient initially responded well to trimethoprim-sulfamethoxazole but faced a recurrence after 9 months, leading to a change in treatment to oral gentamicin, which resulted in remission.