Publications by authors named "A M Oberbauer"
Article Synopsis
- Idiopathic epilepsy (IE) primarily affects Belgian shepherd dogs, and while past studies found genomic markers, specific causative variants remain unidentified.
- The study used RNA sequencing to analyze blood gene expression differences linked to IE and a known risk haplotype on canine chromosome 14.
- Findings showed certain genes related to seizure activity were upregulated, while others involved in the interferon signaling pathway were downregulated, suggesting important genetic factors contributing to IE.
Article Synopsis
- Gastric cancer (GC) is the fifth most common cancer globally, but its genetic causes are not well understood, prompting research using dog breeds known to develop this cancer.
- A study identified 15 genetic loci that predict the risk of GC in Belgian Tervuren and Sheepdog breeds, highlighting specific genetic variants that may contribute to the disease.
- Interestingly, the related Belgian Malinois breed shows lower GC incidence, suggesting protective genetic traits which were also investigated, revealing differences in regulatory variants among the breeds.
The Wnt signaling pathway is critical for normal embryonic development. Disruptions in the Wnt signaling pathway have been linked to neurological disorders. The RAPGEF5 protein is a partner in Wnt signaling and a RAPGEF5 3-bp insertion is associated with increased risk for idiopathic epilepsy in the Belgian shepherd dog.
View Article and Find Full Text PDFIdiopathic epilepsy (IE) has been known to be inherited in the Belgian Tervuren for many decades. Risk genotypes for IE in this breed have recently been identified on Canis familiaris chromosomes (CFA) 14 and 37. In the current study, the allele frequencies of these loci were analyzed to determine whether dog breeders had employed a purposeful selection against IE, leading to a reduction in risk-associated allele frequency within the breed over time.
View Article and Find Full Text PDFGastric carcinoma is generally considered to be a rare disease in dogs, carrying a grave prognosis. However, in the Tervueren and Groenendael varieties of the Belgian Shepherd dog breed, the disease is highly prevalent. While histopathology is the gold standard for diagnosing gastric carcinoma, there is no general consensus on the methods for histological classification in these cases.
View Article and Find Full Text PDF